Department of Anaesthesiology and Intensive Care Medicine, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany.
Practice of Anaesthesia and Pain Therapy, Bonn, Germany.
Pain Ther. 2014 Dec;3(2):85-101. doi: 10.1007/s40122-014-0028-0. Epub 2014 Oct 25.
Patients with fibromyalgia syndrome (FMS) generally present with chronic widespread pain, accompanied by a range of additional and non-specific symptoms, such as fatigue, disturbed sleep, and cognitive dysfunction, which tend to increase with overall severity. Previous studies have shown moderate cognitive impairment in patients with FMS, but there are few valid data explicitly assessing the relevance of these findings to everyday functions, such as driving ability. Therefore, we studied patients with FMS to assess the impact of FMS on tests that predict driving ability.
Female patients with FMS were prospectively compared to a historical control group of healthy volunteers. The test battery comprised assessments of visual orientation, concentration, attention, vigilance, motor coordination, performance under stress, and reaction time.
A total of 43 patients were matched to 129 controls. The results indicated that the patients' psychomotor and cognitive performances were significantly non-inferior when compared to healthy controls (with 0.05% alcohol), with the exception of motor coordination. Patients and healthy controls showed an age-related decline in test performance. Correlations were smaller in patients and reversed for vigilance which was linked to a greater FMS symptom load in younger patients.
The results of the present study demonstrate that, in general, the driving ability of patients with FMS was not inferior to that of healthy volunteers based on a standardized computer-based test battery. However, variables, such as younger age, depression, anxiety, fatigue, pain, and poor motor coordination, likely contribute to the subjective perception of cognitive dysfunction in FMS.
纤维肌痛综合征（FMS）患者通常表现为慢性广泛性疼痛，伴有一系列额外的非特异性症状，如疲劳、睡眠障碍和认知功能障碍，这些症状往往随着整体严重程度的增加而加重。先前的研究表明，FMS 患者存在中度认知障碍，但很少有明确评估这些发现与日常功能（如驾驶能力）相关性的有效数据。因此，我们研究了 FMS 患者，以评估 FMS 对预测驾驶能力的测试的影响。
前瞻性地将女性 FMS 患者与一组健康志愿者的历史对照组进行比较。测试组合包括视觉定向、注意力、警觉性、注意力集中、运动协调、应激下的表现和反应时间评估。
共 43 例患者与 129 例对照组相匹配。结果表明，与健康对照组（含 0.05%酒精）相比，患者的精神运动和认知表现除运动协调外，均显著优于对照组（无统计学差异）。患者和健康对照组的测试表现均随年龄的增长而下降。患者的相关性较小，而警觉性则相反，这与年轻患者 FMS 症状负担较大有关。
本研究结果表明，一般来说，根据标准化的基于计算机的测试组合，FMS 患者的驾驶能力并不逊于健康志愿者。然而，年龄较小、抑郁、焦虑、疲劳、疼痛和运动协调能力差等变量可能导致 FMS 患者对认知功能障碍的主观感知。
