Peres Klein Caroline, Rodrigues Cintra Marcos, Binda Nancy, Montijo Diniz Danuza, Gomez Marcus Vinicius, Souto Andre Arigony, de Souza Alessandra Hubner
Postgraduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil.
Postgraduate Program in Genetics and Applied Toxicology, Lutheran University of Brazil, 92425-900 Canoas, RS, Brazil.
Pain Res Treat. 2016;2016:3191638. doi: 10.1155/2016/3191638. Epub 2016 Mar 16.
The mechanism underlying pain symptoms in fibromyalgia (FM) is not fully understood. Oxidative stress has emerged as pathophysiological event occurring during the development of the disease. The present study aimed at investigating the efficacy of resveratrol associated with rice bran oil on fibromyalgia-like mice model. Subcutaneous injection of reserpine (0.25 mg/Kg) during 3 days produced fibromyalgia-like symptoms. Resveratrol and/or rice oil or pregabalin were administered through oral route in therapeutic (single dose) and preventive (four doses) schemes. In both schemes, treatment with resveratrol associated with rice bran oil and pregabalin significantly reduced mechanical allodynia and thermal hyperalgesia in animals. The preventive scheme displayed antidepressant effect which was demonstrated by the forced swimming test as well as reduced reactive species in the cerebrospinal fluid of reserpinized animals. Taken together, our data provide evidences that the intake of resveratrol associated with rice bran oil plays antinociceptive and antidepressant actions probably through reducing reactive species and suggests the involvement of oxidative stress in this model of FM as possible underlying mechanism of pathogenesis of the disease.
纤维肌痛（FM）疼痛症状的潜在机制尚未完全明确。氧化应激已成为该疾病发展过程中发生的病理生理事件。本研究旨在探讨白藜芦醇联合米糠油对纤维肌痛样小鼠模型的疗效。连续3天皮下注射利血平（0.25mg/Kg）可产生纤维肌痛样症状。白藜芦醇和/或米糠油或普瑞巴林通过口服途径以治疗（单剂量）和预防（四剂量）方案给药。在这两种方案中，白藜芦醇联合米糠油和普瑞巴林治疗均显著减轻了动物的机械性异常性疼痛和热痛觉过敏。预防方案显示出抗抑郁作用，这通过强迫游泳试验得到证实，同时利血平化动物脑脊液中的活性物质也有所减少。综上所述，我们的数据表明，摄入白藜芦醇联合米糠油可能通过减少活性物质发挥抗伤害感受和抗抑郁作用，并提示氧化应激参与该纤维肌痛模型，可能是该疾病发病机制的潜在机制。
