Luo Xiao, Wang Yupeng, Wang Zhiqiang, Zhou Xiao-Hua, Zhao Jing, Suo Jianing, Dong Xiaohui, Liu Meina
Public Health College, Harbin Medical University, 157 Baojian Road, Harbin City, Heilongjiang Province Postcode 150081, P,R, China.
BMC Public Health. 2014 Oct 26;14:1105. doi: 10.1186/1471-2458-14-1105.
There is an ongoing debate on the potential association between obesity and atopy. However, no previous studies have investigated whether this relationship depends on sex and smoking status in Chinese adults.
In this hospital-based, case-control study, we recruited 1150 atopic cases aged 18 years or older and 1245 healthy control participants during April 2009 and December 2012 in Harbin, China. We conducted structured questionnaire interviews, anthropometry measurements and serum allergen-specific immunoglobulin E (IgE) testing. Univariate and multivariate logistic regression models were used to explore the relationship between obesity and atopy risk stratified by sex and smoking status.
There was an association between obesity and an increased risk of atopic sensitization after adjusting for age, educational, family history, smoking and alcohol consumption (OR: 2.61, 3.25; 95% CI: 1.57-4.33,1.91-5.56 in males and females, respectively). The association between BMI and allergic sensitization depended on smoking status. In both genders, the association of obesity with atopic sensitization risk was stronger in non-smokers than in current smokers. In males, ORs of atopic sensitization for obesity were 3.15 (95% CI, 1.46-6.68) for non-smokers and 2.22 (95% CI, 1.10-4.48) for current smokers. The corresponding ORs in females were 3.51 (95% CI, 1.98-6.24) and 2.22 (95% CI, 0.46-10.68) for non-smokers and current smokers, respectively. After excluding those subjects who with pre-existing allergic conditions, the same relationship still remained.
Obesity is positively and significantly associated with the risk of atopy in both men and women as well in both smokers and non-smokers in China. In addition, the relationship between obesity and atopic sensitization is stronger in non-smokers than in current smokers.
肥胖与特应性之间的潜在关联一直存在争议。然而，之前尚无研究调查过在中国成年人中这种关系是否取决于性别和吸烟状况。
在这项基于医院的病例对照研究中，我们于2009年4月至2012年12月期间在中国哈尔滨招募了1150名18岁及以上的特应性病例和1245名健康对照参与者。我们进行了结构化问卷调查、人体测量以及血清过敏原特异性免疫球蛋白E（IgE）检测。采用单因素和多因素逻辑回归模型，按性别和吸烟状况分层，探讨肥胖与特应性风险之间的关系。
在调整年龄、教育程度、家族史、吸烟和饮酒情况后，肥胖与特应性致敏风险增加之间存在关联（男性和女性的比值比分别为：2.61、3.25；95%置信区间分别为：1.57 - 4.33、1.91 - 5.56）。体重指数（BMI）与过敏致敏之间的关联取决于吸烟状况。在两性中，肥胖与特应性致敏风险的关联在非吸烟者中比在当前吸烟者中更强。在男性中，非吸烟者肥胖导致特应性致敏的比值比为3.15（95%置信区间，1.46 - 6.68），当前吸烟者为2.22（95%置信区间，1.10 - 4.48）。女性中，非吸烟者和当前吸烟者相应的比值比分别为3.51（95%置信区间，1.98 -
6.24）和2.22（95%置信区间，0.46 - 10.68）。排除那些已有过敏疾病的受试者后，同样的关系依然存在。
在中国，肥胖与男性和女性、吸烟者和非吸烟者的特应性风险均呈正相关且具有显著意义。此外，肥胖与特应性致敏之间的关系在非吸烟者中比在当前吸烟者中更强。
