Public Health College, Harbin Medical University, 157 Baojian Road, Haerbin City, Heilongjiang Province Postcode 150081, People's Republic of China.
BMC Public Health. 2013 Jan 8;13:12. doi: 10.1186/1471-2458-13-12.
Obesity is regarded as a potential risk factor for atopy. The aim of this study was to assess the associations of obesity with atopic dermatitis, rhinitis, asthma and food allergy in Chinese adults.
Two hundred and sixty six (266) atopic cases in Harbin, China, were identified according to the current Chinese guidelines for the diagnosis of atopic diseases. All cases had a previous diagnosis of atopic disorders (atopic dermatitis, rhinitis, asthma or food allergy) and were positive in one or more allergen specific IgE tests to 16 common allergens in the region. Each case was individually matched to two healthy controls based on their age, sex, and residential regions. All 532 healthy controls were negative in allergen specific IgE tests. The associations of obesity with four atopic disorders were assessed using a conditional logistic regression method.
Obesity was significantly associated with the presence of atopic diseases (OR = 3.2, 95% CI: 1.8, 5.7). Males and females had a similar association (OR = 3.1 for males and 3.2 for females). The associations of obesity with atopic dermatitis (OR = 2.7, 95% CI: 1.2, 6.3) and atopic rhinitis (OR = 3.1, 95% CI: 1.1, 8.7) were statistically significant. Although obesity was positively associated with atopic asthma, this association was not statistically significant (OR = 3.4, 95% CI: 0.6, 19.9). The association between obesity and food allergy was weak and not significant (OR = 1.1, 95% CI: 0.4, 3.7).
Obesity is positively associated with the presence of atopic diseases in Chinese adults. Specifically, obesity is significantly associated with atopic dermatitis and rhinitis. Our findings warrant further investigation on the causal nature between obesity and atopic diseases and the effect of weight reduction on preventing atopic diseases.
肥胖被认为是特应性的潜在危险因素。本研究旨在评估肥胖与中国成年人特应性皮炎、鼻炎、哮喘和食物过敏的关系。
根据目前中国特应性疾病的诊断标准，在中国哈尔滨确定了 266 例特应性病例。所有病例均有特应性疾病（特应性皮炎、鼻炎、哮喘或食物过敏）的既往诊断，并在该地区 16 种常见过敏原的一种或多种过敏原特异性 IgE 检测中呈阳性。根据年龄、性别和居住地区，将 532 名健康对照者与每例特应性病例进行一对一匹配。所有 532 名健康对照者的过敏原特异性 IgE 检测均为阴性。采用条件 logistic 回归方法评估肥胖与四种特应性疾病的关系。
肥胖与特应性疾病的发生显著相关（OR=3.2，95%CI：1.8，5.7）。男性和女性的相关性相似（男性 OR=3.1，女性 OR=3.2）。肥胖与特应性皮炎（OR=2.7，95%CI：1.2，6.3）和特应性鼻炎（OR=3.1，95%CI：1.1，8.7）的相关性有统计学意义。虽然肥胖与特应性哮喘呈正相关，但无统计学意义（OR=3.4，95%CI：0.6，19.9）。肥胖与食物过敏的相关性较弱且无统计学意义（OR=1.1，95%CI：0.4，3.7）。
肥胖与中国成年人特应性疾病的发生呈正相关。具体而言，肥胖与特应性皮炎和鼻炎显著相关。我们的研究结果需要进一步研究肥胖与特应性疾病之间的因果关系，以及减肥对预防特应性疾病的作用。
