Zeglam Adel M, Al-Ogab Marwa F, Al-Shaftery Thouraya
Al-Khadra Teaching Hospital, Tripoli, Libya,
Acta Neurol Belg. 2015 Sep;115(3):351-4. doi: 10.1007/s13760-014-0384-x. Epub 2014 Oct 26.
To evaluate the routine usage of Magnetic Resonance Imaging (MRI) of brain and estimate the prevalence of brain abnormalities in children presenting to the Neurodevelopment Clinic of Al-Khadra Hospital (NDC-KH), Tripoli, Libya with autistic spectrum disorders (ASD). The records of all children with ASD presented to NDC-KH over 4-year period (from January 2009 to December 2012) were reviewed. All MRIs were acquired with a 1.5-T Philips (3-D T1, T2, FLAIR coronal and axial sequences). MRIs were reported to be normal, abnormal or no significant abnormalities by a consultant neuroradiologist. One thousand and seventy-five children were included in the study. Seven hundred and eighty-two children (72.7 %) had an MRI brain of whom 555 (71 %) were boys. 26 children (24 males and 2 females) (3.3 %) demonstrated MRI abnormalities (8 leukodystrophic changes, 4 periventricular leukomalacia, 3 brain atrophy, 2 tuberous sclerosis, 2 vascular changes, 1 pineoblastoma, 1 cerebellar angioma, 1 cerebellar hypoplasia, 3 agenesis of corpus callosum, 1 neuro-epithelial cyst). An unexpectedly high rate of MRI abnormalities was found in the first large series of clinical MRI investigations in children with autism. These results could contribute to further research into the pathogenesis of autistic spectrum disorder.
为评估脑部磁共振成像（MRI）的常规使用情况，并估计在利比亚的黎波里的哈德拉医院神经发育诊所（NDC-KH）就诊的患有自闭症谱系障碍（ASD）的儿童中脑部异常的患病率。回顾了在4年期间（从2009年1月至2012年12月）到NDC-KH就诊的所有ASD儿童的记录。所有MRI均采用1.5-T飞利浦设备采集（三维T1、T2、液体衰减反转恢复序列冠状位和轴位成像）。一位神经放射科顾问医生将MRI报告为正常、异常或无明显异常。1075名儿童纳入本研究。782名儿童（72.7%）进行了脑部MRI检查，其中555名（71%）为男孩。26名儿童（24名男性和2名女性）（3.3%）显示MRI异常（8例脑白质营养不良改变、4例脑室周围白质软化、3例脑萎缩、2例结节性硬化、2例血管改变、1例松果体母细胞瘤、1例小脑血管瘤、1例小脑发育不全、3例胼胝体发育不全、1例神经上皮囊肿）。在针对自闭症儿童的首个大型临床MRI研究系列中发现了意外高的MRI异常率。这些结果可能有助于进一步研究自闭症谱系障碍的发病机制。
