University Hospital Motol and Charles University, Second Faculty of Medicine, Department of Child Psychiatry, Prague, Czech Republic.
Charles University, First Faculty of Medicine, Prague, Czech Republic.
J Appl Biomed. 2021 May;19(2):91-96. doi: 10.32725/jab.2021.009. Epub 2021 Apr 14.
The aim of the present research has been to determine whether there is a relationship between brain abnormalities found on magnetic resonance imaging (MRI) and autistic psychopathology. A retrospective analysis covering a period between 1998 and 2015 included 489 children with autism (404 boys, 85 girls; average age 8.0 ± 4.2 years) who underwent an MRI of the brain. For clinical diagnosis of autism, the International Classification of Diseases, 10th revision (ICD-10), was used. Autistic psychopathology was evaluated by means of the Autism Diagnostic Interview - Revised. The Spearman nonparametric correlation analysis and chi-square test were used to examine the possible relationships between variables. The group of autistic children did not manifest a statistically significant correlation between the parameters examined on MRI and autistic psychopathology. A correlation between other cysts and repetitive behavior was significant only at trend level (P = 0.054). Gliosis of the brain was significantly more frequent in autistic children with mental retardation than in children without mental retardation (14.1% vs. 7.4%; P = 0.028). Nonmyelinated areas in the brain were significantly more frequent in autistic children with autistic regression than in children without autistic regression (29.9% vs. 15.7%; P = 0.008). Mental retardation was significantly more frequent in autistic children with autistic regression than in children without regression (73.2% vs. 52.5%; P = 0.002). Our research study did not reveal a statistically significant correlation of brain abnormalities on MRI with autistic psychopathology.
本研究旨在确定磁共振成像（MRI）发现的大脑异常与自闭症病理之间是否存在关系。回顾性分析涵盖了 1998 年至 2015 年期间的 489 名自闭症儿童（404 名男孩，85 名女孩；平均年龄 8.0±4.2 岁），他们均接受了脑部 MRI 检查。自闭症的临床诊断采用国际疾病分类，第 10 版（ICD-10）。自闭症病理采用自闭症诊断访谈修订版进行评估。采用 Spearman 非参数相关性分析和卡方检验来检查变量之间的可能关系。自闭症儿童组的 MRI 检查参数与自闭症病理之间未表现出统计学显著相关性。其他囊肿与重复行为之间的相关性仅在趋势水平上具有统计学意义（P=0.054）。脑白质营养不良在智障自闭症儿童中比在非智障自闭症儿童中更为常见（14.1%比 7.4%；P=0.028）。自闭症退行性自闭症儿童的脑未髓鞘化区比非自闭症退行性自闭症儿童更为常见（29.9%比 15.7%；P=0.008）。自闭症退行性自闭症儿童的智力障碍比非退行性自闭症儿童更为常见（73.2%比 52.5%；P=0.002）。我们的研究未发现 MRI 上的大脑异常与自闭症病理之间存在统计学显著相关性。
