Axl作为细胞生长和存活的介质。
Axl as a mediator of cellular growth and survival.
作者信息
Axelrod Haley, Pienta Kenneth J
机构信息
The Cellular and Molecular Medicine Program, The Johns Hopkins School of Medicine, Baltimore, MD, USA. The James Buchanan Brady Urological Institute, Departments of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
The Cellular and Molecular Medicine Program, The Johns Hopkins School of Medicine, Baltimore, MD, USA. The James Buchanan Brady Urological Institute, Departments of Urology, The Johns Hopkins School of Medicine, Baltimore, MD, USA. Oncology, The Johns Hopkins School of Medicine, Baltimore, MD, USA. Pharmacology and Molecular Sciences, The Johns Hopkins School of Medicine, Baltimore, MD, USA. Departments of Chemical and Biomolecular Engineering, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
出版信息
Oncotarget. 2014 Oct 15;5(19):8818-52. doi: 10.18632/oncotarget.2422.
The control of cellular growth and proliferation is key to the maintenance of homeostasis. Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) through binding to members of the TAM receptor tyrosine kinase family. Activation of the TAM receptors leads to downstream signaling through common kinases, but the exact mechanism within each cellular context varies and remains to be completely elucidated. Deregulation of the TAM family, due to its central role in mediating cellular proliferation, has been implicated in multiple diseases. Axl was cloned as the first TAM receptor in a search for genes involved in the progression of chronic to acute-phase leukemia, and has since been established as playing a critical role in the progression of cancer. The oncogenic nature of Axl is demonstrated through its activation of signaling pathways involved in proliferation, migration, inhibition of apoptosis, and therapeutic resistance. Despite its recent discovery, significant progress has been made in the development of effective clinical therapeutics targeting Axl. In order to accurately define the role of Axl in normal and diseased processes, it must be analyzed in a cell type-specific context.
细胞生长和增殖的控制是维持体内平衡的关键。生存、增殖和停滞部分受生长停滞特异性蛋白6（Gas6）调节，它通过与TAM受体酪氨酸激酶家族成员结合来发挥作用。TAM受体的激活通过常见激酶导致下游信号传导，但在每种细胞环境中的具体机制各不相同，仍有待完全阐明。由于TAM家族在介导细胞增殖中起核心作用，其失调与多种疾病有关。Axl作为第一个TAM受体被克隆，当时是在寻找与慢性白血病向急性期白血病进展相关的基因，此后已确定它在癌症进展中起关键作用。Axl的致癌性质通过其对参与增殖、迁移、抑制细胞凋亡和治疗抗性的信号通路的激活得以证明。尽管它是最近才被发现的，但在开发针对Axl的有效临床治疗方法方面已取得了重大进展。为了准确界定Axl在正常和疾病过程中的作用，必须在细胞类型特异性背景下对其进行分析。
Zotero 插件