[常见环氧化酶-2（COX-2）基因多态性与冠心病患者临床及血管造影特征的关联]
[Association of common cyclooxygenase-2 (COX-2) gene polymorphisms with clinical and angiographic characteristics of patients with coronary artery disease].
作者信息
Rostoff Pawel, Szczeklik Wojciech, Piwowarska Wieslawa, Konduracka Ewa, Sanak Marek, Nessler Jadwiga
出版信息
Przegl Lek. 2014;71(6):314-8.
BACKGROUND
Chronic inflammation of the arterial wall plays a crucial role in the pathogenesis of atherosclerosis. Cyclooxygenase-2 (COX-2) is a key enzyme in the synthesis of proinflammatory prostanoids. At least two of the common genetic polymorphisms of the COX-2 gene have phenotypic effects: G-765C (rs20417) and T8473C (rs5275).
AIM
To assess the relation of G-765C and T8473C COX-2 polymorphisms to clinical and angiographic characteristics of patients with coronary artery disease (CAD).
MATERIAL AND METHODS
The study comprised 186 consecutive patients with angiographically defined CAD (> or =70% stenosis of > or =1 coronary artery). The study population were divided into two groups: A-123 patients with stable angina (mean age, 62.6 +/- 11.2 years; 30.1% women), and B-63 patients with unstable angina (mean age, 64.0 +/- 10.8 years; 19.0% women). The controls comprised 70 individuals without symptoms of CAD (mean age, 37.6 +/- 9.9 years; 57.1% women). Results: No significant differences were observed in -765C and 8473C allele frequencies between the patients with CAD and control subjects. In CAD patients, the studied COX-2 polymorphisms were not significantly associated with the age of the onset of symptoms and clinical presentation of CAD. In the B group, a difference was observed within the frequency of significant (>50%) left main coronary artery stenosis (LMCAS) and/or three-vessel CAD (3-CAD) between the -765C allele carriers and 765G 765G homozygotes (14.3% vs. 49.0%; p=0.044). In the CAD patients (group A and group B) the prevalence of LMCAS and/or 3-CAD was significantly lower among 365C allele carriers (22.8% vs. 40.3%:
CONCLUSIONS
There were no significant differences in -765C and 8473C allele frequencies between patients with CAD and subjects without symptoms of CAD; In patients with CAD, COX-2 G-765C and T8473C polymorphisms had no significant association with the age of the onset of symptoms and clinical presentation of ischaemic heart disease; The G-765C COX-2 polymorphism is associated with less frequent occurrence of multivessel CAD in the studied population. p=0.021
背景
动脉壁的慢性炎症在动脉粥样硬化的发病机制中起关键作用。环氧化酶-2（COX-2）是促炎前列腺素合成中的关键酶。COX-2基因至少两种常见的基因多态性具有表型效应：G-765C（rs20417）和T8473C（rs5275）。
目的
评估COX-2基因G-765C和T8473C多态性与冠心病（CAD）患者临床及血管造影特征的关系。
材料与方法
该研究纳入186例经血管造影确诊为CAD（≥1支冠状动脉狭窄≥70%）的连续患者。研究人群分为两组：A组-123例稳定型心绞痛患者（平均年龄62.6±11.2岁；女性占30.1%），B组-63例不稳定型心绞痛患者（平均年龄64.0±10.8岁；女性占19.0%）。对照组包括70例无CAD症状的个体（平均年龄37.6±9.9岁；女性占57.1%）。结果：CAD患者与对照组之间，-765C和8473C等位基因频率无显著差异。在CAD患者中，所研究的COX-2多态性与症状发作年龄及CAD临床表现无显著关联。在B组中，-765C等位基因携带者与765G 765G纯合子之间，左主干冠状动脉狭窄（LMCAS）和/或三支血管CAD（3-CAD）显著（>50%）的频率存在差异（14.3%对49.0%；p=0.044）。在CAD患者（A组和B组）中，365C等位基因携带者中LMCAS和/或3-CAD的患病率显著较低（22.8%对40.3%：
结论
CAD患者与无CAD症状的个体之间，-765C和8473C等位基因频率无显著差异；在CAD患者中，COX-2 G-765C和T8473C多态性与缺血性心脏病症状发作年龄及临床表现无显著关联；在研究人群中，COX-2 G-765C多态性与多支血管CAD的发生频率较低相关。p=0.021
Zotero 插件