Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education & Sino-German Laboratory for Molecular Medicine, Cardiovascular Institute & Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Atherosclerosis. 2009 Dec;207(2):492-5. doi: 10.1016/j.atherosclerosis.2009.06.029. Epub 2009 Jul 8.
Previous case-control studies suggested the single nucleotide polymorphism of cyclooxygenase-2 (COX-2) gene (G-765C) is associated with coronary artery disease (CAD) and ischemic stroke. However, other studies did not confirm this relationship. The objective was to assess the relationship of COX-2 G-765C and CAD and ischemic stroke, using a meta-analysis.
Databases, including PubMed, EMbase, CBM and CNKI, were searched to get the genetic association studies. Data were extracted by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.
The meta-analysis included 4930 CAD patients and 17,997 controls, as well as 1628 ischemic stroke patients and 17,653 controls. For CAD, the pooled OR of -765C was 0.80 (95%CI: 0.65-0.98) compared to wild type allele in recessive model, and was 0.99 (95%CI: 0.92-1.06) in dominant model. For ischemic stroke, the pooled OR of -765C was 1.11 (95%CI: 0.88-1.42) in recessive model compared to wild type allele, and was 1.05 (95%CI: 0.93-1.18) in dominant model. No publication bias was found in this meta-analysis.
The synthesis of available evidence supports that the COX-2 G-765C is protective for CAD. However, it is not associated with ischemic stroke.
先前的病例对照研究表明，环氧化酶-2（COX-2）基因的单核苷酸多态性（G-765C）与冠状动脉疾病（CAD）和缺血性中风有关。然而，其他研究并未证实这种关系。本研究旨在通过荟萃分析评估 COX-2 G-765C 与 CAD 和缺血性中风的关系。
通过检索 PubMed、EMbase、CBM 和 CNKI 等数据库，获取基因关联研究。由两位作者提取数据，并计算合并优势比（OR）及其 95%置信区间（CI）。
该荟萃分析纳入了 4930 例 CAD 患者和 17997 例对照，以及 1628 例缺血性中风患者和 17653 例对照。对于 CAD，在隐性模型中，与野生型等位基因相比，-765C 的合并 OR 为 0.80（95%CI：0.65-0.98），在显性模型中为 0.99（95%CI：0.92-1.06）。对于缺血性中风，在隐性模型中，与野生型等位基因相比，-765C 的合并 OR 为 1.11（95%CI：0.88-1.42），在显性模型中为 1.05（95%CI：0.93-1.18）。本荟萃分析未发现发表偏倚。
现有证据的综合分析支持 COX-2 G-765C 对 CAD 具有保护作用。然而，它与缺血性中风无关。
