Posadzka Ewa, Jach Robert, Babczyk Dorota, Knafel Anna, Pityński Kazimierz
Przegl Lek. 2014;71(6):319-22.
Cancer antigen CA-125 is a marker that is primarily used to differentiate benign from malignant tumors as well as to monitor response to ovarian cancer treatment. Taken as a separate marker, it displays low sensitivity and specificity in ovarian cancer diagnosis; however, in combination with other markers it may be successfully applied especially in postmenopausal women. Elevated CA-125 levels in blood serum indicate cancerous as well as non-cancerous diseases. Research aiming to determine environmental factors that may have influence on antigen CA-125 level, and thus on the assessment of this marker's application in gynecological and oncological diseases continues.
the aim of the present research is an attempt to estimate the influence of nicotinism on antigen CA-125 in blood serum in patients with diagnosed benign ovarian tumors including endometrial cysts.
174 women aged 16-85 years with diagnosed benign ovarian tumor were qualified for the study. In all patients level of antigen CA-125 in blood serum was assessed preoperatively and nicotinism history was taken. Also transvaginal ultrasound was performed to obtain preliminary diagnosis. Smoking and non-smoking patients were classified into two groups, namely of those with histopathologically confirmed cysts of endometrial type and those with non-endometrial benign ovarian tumors.
statistical analysis did not prove any dependence between the CS-125 antigen level and nicotinism in any of these groups. Also additional analysis with division into premenopausal and postmenopausal patients did not determine any statistically significant dependence.
Nicotinism does not significantly influence the CA-125 antigen level in patients with benign However, the connection between the addiction severity and its influence on antigen CA-125 in blood serum cannot be excluded. ovarian tumors or endometrial cysts.
癌症抗原CA - 125是一种主要用于区分良性肿瘤与恶性肿瘤以及监测卵巢癌治疗反应的标志物。单独作为一种标志物，它在卵巢癌诊断中显示出低敏感性和特异性；然而，与其他标志物联合使用时，它可能会成功应用，特别是在绝经后女性中。血清中CA - 125水平升高表明存在癌症以及非癌症疾病。旨在确定可能影响抗原CA - 125水平，进而影响该标志物在妇科和肿瘤疾病中应用评估的环境因素的研究仍在继续。
本研究旨在尝试评估吸烟对诊断为良性卵巢肿瘤（包括子宫内膜囊肿）患者血清中抗原CA - 125的影响。
174名年龄在16 - 85岁、诊断为良性卵巢肿瘤的女性符合研究条件。所有患者术前均评估了血清中抗原CA - 125水平并记录了吸烟史。还进行了经阴道超声检查以获得初步诊断。吸烟和不吸烟患者被分为两组，即组织病理学确诊为子宫内膜型囊肿的患者和非子宫内膜型良性卵巢肿瘤患者。
统计分析未证明这些组中的任何一组中CS - 125抗原水平与吸烟之间存在任何相关性。将患者分为绝经前和绝经后患者的进一步分析也未确定任何统计学上的显著相关性。
吸烟对患有良性卵巢肿瘤或子宫内膜囊肿的患者的CA - 125抗原水平没有显著影响。然而，不能排除成瘾严重程度与其对血清中抗原CA - 125的影响之间的联系。
