Shang Xiaoli, Liabsuetrakul Tippawan, Sangsupawanich Pasuree, Xia Xiaoling, He Ping, Cao Hong
J Med Assoc Thai. 2014 Aug;97(8):827-34.
To investigate the effect of cesarean delivery and other predisposing factors of respiratory syncytial virus (RSV)-positive acute bronchiolitis in children.
The case-control study was conducted in three main tertiary hospitals in Kunming, China between September 2012 and July 2013. Children with first episode of wheezing diagnosed as bronchiolitis and testedfor RSV were included RSV was detected by real-time reverse transcription polymerase chain reaction. Mode ofdelivery and characteristics of children, parents, and household were interviewed and analyzed with RSV-positive status by multiple logistic regression.
Of 265 children, RSV-positive was found in 75.5%, and the majority of children (83.3%) were younger than 12 months. Compared to vaginal delivery, the odds of RSV-positive detection were double in children born by elective cesarean delivery (adjusted odds ratio 2.32; 95% confidence interval 1.19-4.52). Children aged less than 6 months, born in the rainy season, having maternal history of asthma and living in family that smoked more than 20 cigarettes per day were more likely to be RSV-positive.
Children born by elective cesarean delivery increased the risk of RSV-positive acute bronchiolitis after adjusting for age, birth season, maternal asthma, and family smoking status.
探讨剖宫产及其他易感因素对儿童呼吸道合胞病毒（RSV）阳性急性细支气管炎的影响。
2012年9月至2013年7月在中国昆明的三家主要三级医院开展病例对照研究。纳入首次喘息发作诊断为细支气管炎且检测RSV的儿童，采用实时逆转录聚合酶链反应检测RSV。通过多因素logistic回归分析分娩方式以及儿童、父母和家庭的特征与RSV阳性状态的关系。
265名儿童中，75.5%检测出RSV阳性，大多数儿童（83.3%）年龄小于12个月。与阴道分娩相比，择期剖宫产出生的儿童RSV阳性检测几率翻倍（校正比值比2.32；95%置信区间1.19 - 4.52）。年龄小于6个月、在雨季出生、母亲有哮喘病史且家庭每日吸烟超过20支的儿童更易RSV阳性。
校正年龄、出生季节、母亲哮喘和家庭吸烟状况后，择期剖宫产出生的儿童患RSV阳性急性细支气管炎的风险增加。
