Meyer zum Gottesberge A, Lamprecht J
Department of Otorhinolaryngology, University of Düsseldorf, FRG.
Acta Otolaryngol Suppl. 1989;468:53-7. doi: 10.3109/00016488909139021.
Specific high affinity atrial natriuretic peptide (ANP) binding sites were identified and localized by autoradiography (125J-ANP 1-28) in the inner ear of guinea pigs. ANP is a cardiac hormone known to mediate increased capillary permeability, vasodilation, and natriuresis. Since specific receptors for ANP exist in both eye and brain, possibly playing a role in regulation of fluid and pressure (14, 15), we hypothetized that ANP might be involved also in inner ear fluid dynamics via interaction with other volume/electrolyte balance regulating hormones including vasopressin, renin, and aldosteron. The distribution of ANP receptor in the inner ear tissue appears unequal, which may play a significant role in view of some functional disturbances such as Meniere's disease.
通过放射自显影法（¹²⁵I - 心房钠尿肽1 - 28）在豚鼠内耳中鉴定并定位了特异性高亲和力心房钠尿肽（ANP）结合位点。ANP是一种心脏激素，已知其可介导毛细血管通透性增加、血管舒张和利钠作用。由于ANP的特异性受体存在于眼睛和大脑中，可能在液体和压力调节中发挥作用（参考文献14、15），我们推测ANP可能也通过与其他调节容量/电解质平衡的激素（包括血管加压素、肾素和醛固酮）相互作用而参与内耳的液体动力学。内耳组织中ANP受体的分布似乎不均匀，鉴于一些功能障碍（如梅尼埃病），这可能起着重要作用。
