Meyer zum Gottesberge A M, Gagelmann M, Forssmann W G
Forschungslabor der HNO Klinik der Universität Düsseldorf, F.R.G.
Hear Res. 1991 Nov;56(1-2):86-92. doi: 10.1016/0378-5955(91)90157-5.
Using specific antibodies against cardiodilatin/atrial natriuretic peptide (CDD/ANP) in a conventional immuno-histochemical method (PAP) we located ANP/CDD-like immuno-reactive cells related to the secretory area, to the sensory and to the neuronal area in the compartments of the inner ear (cochlea, utricle/ampulla, and endolymphatic sac). Immunoreactive cells were unevenly distributed in the different compartments as well as within the cochlear space. Our findings suggest that ANP/CDD may play a role in the local control of fluid and electrolyte homeostasis of the inner ear. ANP/CDD-binding sites and ANP/CDD-like immunoreactivity in the inner ear may also indicate that the peptide has an additional paracrine and/or autocrine function in the organ.
采用抗心钠素/心房利钠肽（CDD/ANP）的特异性抗体，运用传统免疫组织化学方法（PAP法），我们在内耳各部分（耳蜗、椭圆囊/壶腹和内淋巴囊）中定位了与分泌区、感觉区及神经区相关的ANP/CDD样免疫反应细胞。免疫反应细胞在不同部分以及耳蜗间隙内分布不均。我们的研究结果表明，ANP/CDD可能在内耳液体和电解质稳态的局部控制中发挥作用。内耳中的ANP/CDD结合位点及ANP/CDD样免疫反应性也可能表明该肽在该器官中具有额外的旁分泌和/或自分泌功能。
