催乳素与自然杀伤细胞：评估原发性不孕和复发性自然流产女性的神经内分泌-免疫轴
Prolactin and natural killer cells: evaluating the neuroendocrine-immune axis in women with primary infertility and recurrent spontaneous abortion.
作者信息
Triggianese Paola, Perricone Carlo, Perricone Roberto, De Carolis Caterina
机构信息
Department of 'Medicina dei Sistemi', Rheumatology, Allergology and Clinical Immunology, University of Rome Tor Vergata, Rome, Italy.
出版信息
Am J Reprod Immunol. 2015 Jan;73(1):56-65. doi: 10.1111/aji.12335. Epub 2014 Oct 24.
PROBLEM
An association between serum prolactin (PRL) and peripheral blood natural killer (NK) cells has been described in healthy women. We explored for the first time the PRL response to the thyrotrophin-releasing hormone (TRH) test and the association between PRL and NK cells in women with reproductive failure.
METHODS
A total of 130 women [31 primary infertility, 69 recurrent spontaneous abortion (RSA), and 30 fertile women] were evaluated by a TRH test to analyze the following: basal PRL (bPRL), peak-time PRL, PRL absolute and relative increase, decline-time PRL. Hyperprolactinaemia (HPRL) was defined as bPRL ≥15 ng/mL. NK cells were characterized by immunophenotyping.
RESULTS
Significantly higher bPRL levels were found in the infertile women than in controls. Both the infertile and the RSA women showed significantly elevated NK levels. bPRL levels correlated with NK cells in HPRL-infertile women.
CONCLUSIONS
In patients with HPRL, an association between NK cell and bPRL results. The dynamic test in the infertile women would help in the management of the pregnancy impairment.
问题
健康女性中血清催乳素（PRL）与外周血自然杀伤（NK）细胞之间存在关联。我们首次探讨了促甲状腺激素释放激素（TRH）试验中PRL的反应以及生殖功能衰竭女性中PRL与NK细胞之间的关联。
方法
通过TRH试验对总共130名女性[31名原发性不孕症患者、69名复发性自然流产（RSA）患者和30名有生育能力的女性]进行评估，以分析以下指标：基础PRL（bPRL）、PRL峰值时间、PRL绝对和相对增加值、PRL下降时间。高催乳素血症（HPRL）定义为bPRL≥15 ng/mL。通过免疫表型分析对NK细胞进行表征。
结果
不孕女性的bPRL水平显著高于对照组。不孕女性和RSA女性的NK水平均显著升高。HPRL不孕女性的bPRL水平与NK细胞相关。
结论
在HPRL患者中，NK细胞与bPRL结果之间存在关联。对不孕女性进行动态试验将有助于妊娠障碍的管理。
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