Stoll C, Alembik Y, Dott B, Finck S
Institut de Puériculture, Centre Hospitalo-Universitaire, Strasbourg, France.
J Genet Hum. 1989 Dec;37(4-5):389-93.
Thyroid function of 60 children with Down (DS) aged 3 months to 16 years was studied by evaluation of serum concentration of ultra-sensitive thyroid stimulating hormone (TSH), free T4 and T3 (FT4, FT3), total T4 and T3 (T4 and T3) and reverse T3 (rT3). Each DS child was matched to a control of the same age. The concentration of TSH was increased in DS children while the concentration of rT3 of the DS children was significantly decreased compared to the controls as was the ratio rT3/TSH. These results showed that thyroid function of DS children is abnormal.
通过评估超敏促甲状腺激素（TSH）、游离T4和T3（FT4、FT3）、总T4和T3（T4和T3）以及反T3（rT3）的血清浓度，对60名年龄在3个月至16岁的唐氏综合征（DS）患儿的甲状腺功能进行了研究。每个DS患儿都与一名同龄对照儿童相匹配。与对照组相比，DS患儿的TSH浓度升高，而DS患儿的rT3浓度以及rT3/TSH比值均显著降低。这些结果表明DS患儿的甲状腺功能异常。
