Macera Márcia A C, Louzada Francisco, Cancho Vicente G, Fontes Cor J F
PPGEs, Universidade Federal de São Carlos, São Carlos, SP, Brazil.
Biom J. 2015 Mar;57(2):201-14. doi: 10.1002/bimj.201300116. Epub 2014 Oct 24.
In this paper, we introduce a new model for recurrent event data characterized by a baseline rate function fully parametric, which is based on the exponential-Poisson distribution. The model arises from a latent competing risk scenario, in the sense that there is no information about which cause was responsible for the event occurrence. Then, the time of each recurrence is given by the minimum lifetime value among all latent causes. The new model has a particular case, which is the classical homogeneous Poisson process. The properties of the proposed model are discussed, including its hazard rate function, survival function, and ordinary moments. The inferential procedure is based on the maximum likelihood approach. We consider an important issue of model selection between the proposed model and its particular case by the likelihood ratio test and score test. Goodness of fit of the recurrent event models is assessed using Cox-Snell residuals. A simulation study evaluates the performance of the estimation procedure in the presence of a small and moderate sample sizes. Applications on two real data sets are provided to illustrate the proposed methodology. One of them, first analyzed by our team of researchers, considers the data concerning the recurrence of malaria, which is an infectious disease caused by a protozoan parasite that infects red blood cells.
在本文中,我们介绍了一种用于复发事件数据的新模型,其特征在于具有完全参数化的基线率函数,该模型基于指数 - 泊松分布。该模型源于潜在的竞争风险情形,即对于事件发生是由哪个原因导致的没有信息。然后,每次复发的时间由所有潜在原因中的最小寿命值给出。新模型有一个特殊情况,即经典的齐次泊松过程。讨论了所提出模型的性质,包括其风险率函数、生存函数和普通矩。推断过程基于最大似然法。我们通过似然比检验和得分检验考虑了所提出模型与其特殊情况之间模型选择的一个重要问题。使用考克斯 - 斯内尔残差评估复发事件模型的拟合优度。一项模拟研究评估了在小样本和中等样本量情况下估计程序的性能。提供了对两个真实数据集的应用以说明所提出的方法。其中之一,由我们的研究团队首次分析,考虑了关于疟疾复发的数据,疟疾是一种由感染红细胞的原生动物寄生虫引起的传染病。