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一种基于乘性边际率函数的间隙时间模型,该函数考虑了零复发单位。

A gap time model based on a multiplicative marginal rate function that accounts for zero-recurrence units.

作者信息

Louzada Francisco, Macera Márcia Ac, Cancho Vicente G

机构信息

Instituto de Ciências Matemáticas e de Computação, Universidade de São Paulo, Brazil.

出版信息

Stat Methods Med Res. 2017 Oct;26(5):2000-2010. doi: 10.1177/0962280217708669. Epub 2017 May 10.

Abstract

In this article, we propose an alternative gap time model based on a multiplicative marginal rate function, which is formulated considering each gap time conditional on the previous recurrence times. In this formulation, the gap times are treated equally and the relation between successive events is no longer a problem. Furthermore, this article considers the inclusion of a proportion of zero-recurrence units (for which the event of interest will not occur) into the model to analyze recurrent event data. Inference aspects of the proposed model are discussed through maximum likelihood approach. A simulation study is carried out to examine the performance of the estimation procedure. The model is applied to hospital readmission data among colorectal cancer patients.

摘要

在本文中,我们基于乘法边际率函数提出了一种替代的间隔时间模型,该模型是在考虑每个间隔时间依赖于先前复发时间的条件下制定的。在此公式中,间隔时间被平等对待,连续事件之间的关系不再是问题。此外,本文考虑将一定比例的零复发单位(即感兴趣的事件不会发生的单位)纳入模型以分析复发事件数据。通过最大似然法讨论了所提出模型的推断方面。进行了一项模拟研究以检验估计程序的性能。该模型应用于结直肠癌患者的医院再入院数据。

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