Sun Xiaomin, Cao Zhen-Bo, Tanisawa Kumpei, Ito Tomoko, Oshima Satomi, Ishimi Yoshiko, Tabata Izumi, Higuchi Mitsuru
Graduate School of Sport Sciences, Waseda University.
J Atheroscler Thromb. 2015;22(4):355-62. doi: 10.5551/jat.26070. Epub 2014 Oct 27.
Low circulating 25-hydroxyvitamin D [25(OH)D] concentration has been linked to a high prevalence of cardiovascular disease. One explanation for this phenomenon is that there is an association between the serum 25(OH)D level and lipid profiles. However, studies examining this relationship are limited and have yielded inconsistent results. We thus aimed to evaluate the association between the serum 25(OH)D concentration and lipid profiles in Japanese men taking into consideration confounding factors, including the visceral fat area (VFA) and cardiorespiratory fitness.
A total of 136 men (age range: 20-79 years) participated in our study. Fasting blood samples were analyzed to determine the 25(OH)D, oxidized low-density lipoprotein (oxLDL), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), apolipoprotein (Apo)A-1 and ApoB levels. The VFA was evaluated on magnetic resonance imaging (MRI), and cardiorespiratory fitness was assessed by measuring the peak oxygen uptake (VO2 peak).
The median 25(OH)D concentration was 35.6 nmol/L, and the prevalence of 25(OH)D deficiency was 78.7%. A multiple linear regression analysis revealed that the serum 25(OH)D concentration was inversely related to the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values, even after adjusting for age, season, smoking status, alcohol consumption, medication use, vitamin D intake, calcium intake, VFA and cardiorespiratory fitness.
Serum 25(OH)D level is inversely correlated with the LDL-C/HDL-C, TG, ApoB and ApoB/ApoA-1 values in Japanese men, independent of the VFA and cardiorespiratory fitness.
循环中25-羟维生素D[25(OH)D]浓度较低与心血管疾病的高患病率相关。对此现象的一种解释是血清25(OH)D水平与血脂谱之间存在关联。然而，研究这种关系的研究有限且结果不一致。因此，我们旨在评估日本男性血清25(OH)D浓度与血脂谱之间的关联，并考虑包括内脏脂肪面积（VFA）和心肺适能在内的混杂因素。
共有136名男性（年龄范围：20 - 79岁）参与了我们的研究。分析空腹血样以测定25(OH)D、氧化型低密度脂蛋白（oxLDL）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、载脂蛋白（Apo）A-1和ApoB水平。通过磁共振成像（MRI）评估VFA，并通过测量峰值摄氧量（VO2峰值）评估心肺适能。
25(OH)D浓度中位数为35.6 nmol/L，25(OH)D缺乏患病率为78.7%。多元线性回归分析显示，即使在调整了年龄、季节、吸烟状况、饮酒、用药、维生素D摄入量、钙摄入量、VFA和心肺适能后，血清25(OH)D浓度仍与LDL-C/HDL-C、TG、ApoB和ApoB/ApoA-1值呈负相关。
在日本男性中，血清25(OH)D水平与LDL-C/HDL-C、TG、ApoB和ApoB/ApoA-1值呈负相关，独立于VFA和心肺适能。
