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作为心血管疾病特征标志物的“维生素D”

"Vitamin D" as a profile marker for cardiovascular diseases.

作者信息

Oberoi Deepak, Mehrotra Vinit, Rawat Anurag

机构信息

Department of Anaesthesiology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

Department of Biochemistry, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.

出版信息

Ann Card Anaesth. 2019 Jan-Mar;22(1):47-50. doi: 10.4103/aca.ACA_66_18.

Abstract

OBJECTIVE

A growing body of research indicates that there exists a correlation between Vit D deficiency and cardiovascular diseases (CVD). In addition to being genetically determined, it is strongly influenced by lifestyle factors. In this study, Vit D and its interrelated factors have been studied as profile marker for identifying the risk of CVD in patients.

METHODS

The present study includes comparison of a total 200 adults CVD patients with the healthy patients as control, by measuring their serum lipid levels and Vit D concentrations with other CVD risk factors.

RESULTS

The average serum Vit D in CVD patients and controls are found to be 22.55±6.2 ng/ml and 37.62±3.2 ng/ml respectively, showing that 63% of CVD patients and 35% of controls are Vit D deficient. Serum lipids levels were considered as marker for patients having CVD which include high levels of total cholesterol, triglycerides, and low-density lipoprotein-cholesterol while low levels of high-density lipoproteins-cholesterol levels. Other risk factors like hypertension, lifestyle, smoking, dietary factors and nutritional status shows significantly correlation for CVD patients compared to controls.

CONCLUSION

Literature supports the relationship between lipid profile and Vit D level by using this as a profile marker for CVD patients. Our study also suggests the same that vitamin D can be used as profile marker for cardiovascular diseases.

摘要

目的

越来越多的研究表明,维生素D缺乏与心血管疾病(CVD)之间存在关联。除了由基因决定外,它还受到生活方式因素的强烈影响。在本研究中,维生素D及其相关因素已被作为识别患者心血管疾病风险的概况标志物进行研究。

方法

本研究包括对总共200名成年心血管疾病患者与作为对照的健康患者进行比较,通过测量他们的血脂水平、维生素D浓度以及其他心血管疾病风险因素。

结果

发现心血管疾病患者和对照组的平均血清维生素D分别为22.55±6.2 ng/ml和37.62±3.2 ng/ml,表明63%的心血管疾病患者和35%的对照组存在维生素D缺乏。血脂水平被视为心血管疾病患者的标志物,包括总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平升高,而高密度脂蛋白胆固醇水平降低。与对照组相比,高血压、生活方式、吸烟、饮食因素和营养状况等其他风险因素在心血管疾病患者中显示出显著相关性。

结论

文献支持通过将血脂谱和维生素D水平之间的关系用作心血管疾病患者的概况标志物。我们的研究也表明维生素D可作为心血管疾病的概况标志物。

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