Ouyang Guang-Hui, He Yan-Mei, Fan Qing-Hua
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190 (P.R. China); Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072 (P.R. China).
Chemistry. 2014 Dec 8;20(50):16454-7. doi: 10.1002/chem.201404605. Epub 2014 Oct 24.
A new kind of podand-based dimeric salen ligand was synthesized, and its association with potassium cations was investigated by (1) H NMR spectroscopy. The corresponding Cr(III) -salen dimer was assembled by a supramolecular host-guest self-assembly process and was then used as a catalyst in highly efficient and enantioselective asymmetric Henry reactions. Regulation by KBArF (BArF =[3,5-(CF3 )2 C6 H3 ]4 B) led to remarkable improvements in yield (by up to 58 %) and enantioselectivity (for example, from 80 % ee to 96 % ee).
合成了一种新型的基于开链多醚的二聚萨伦配体，并通过¹H NMR光谱研究了其与钾阳离子的缔合。相应的Cr(III)-萨伦二聚体通过超分子主客体自组装过程组装而成，然后用作高效对映选择性不对称亨利反应的催化剂。用KBArF（BArF = [3,5-(CF₃)₂C₆H₃]₄B）进行调控可使产率（提高高达58%）和对映选择性（例如，从80% ee提高到96% ee）得到显著改善。
