Mohile Supriya, Dale William, Magnuson Allison, Kamath Nayana, Hurria Arti
James Wilmot Cancer Center, University of Rochester, Rochester, New York, US.
Sections of Geriatrics & Palliative Medicine and Hematology/Oncology, University of Chicago, Chicago, Illinois, US.
Cancer Forum. 2013 Nov;37(3):216-221.
The incidence of cancer increases with advanced age. Unfortunately, there is a significant lack of evidence regarding the safety and efficacy of treatments. The oncology community also lacks information regarding which older patients are most likely to benefit from treatment without undue toxicities. Interventions to lower symptoms and reduce long-term complications from cancer and cancer treatment in older patients are urgently needed. Establishing research priorities in geriatric oncology could help guide researchers and focus efforts on interventions that have the highest likelihood of improving outcomes. The Cancer and Aging Research Group, in partnership with the National Institute on Aging and National Cancer Institute, held linked conferences as part of a U13 grant in September of 2010 and November of 2012, summarising the gaps in knowledge in geriatric oncology and recommending ways to close these gaps. The overall purpose of this review is to highlight the important research priorities in geriatric oncology from the literature and from the previous U13 meetings. More evidence regarding the treatment of older cancer patients is urgently needed given the rapid aging of the population.
癌症发病率随年龄增长而上升。不幸的是，关于治疗的安全性和有效性，证据严重不足。肿瘤学界也缺乏有关哪些老年患者最有可能从治疗中获益而无过度毒性的信息。迫切需要采取干预措施来减轻老年患者癌症及癌症治疗的症状并减少长期并发症。确定老年肿瘤学的研究重点有助于指导研究人员，并将精力集中在最有可能改善治疗结果的干预措施上。癌症与衰老研究小组与美国国立衰老研究所和美国国立癌症研究所合作，作为2010年9月和2012年11月U13资助项目的一部分举办了联合会议，总结了老年肿瘤学知识方面的差距，并提出了缩小这些差距的方法。本综述的总体目的是从文献和之前的U13会议中突出老年肿瘤学的重要研究重点。鉴于人口的快速老龄化，迫切需要更多关于老年癌症患者治疗的证据。
