Török L, Galuska L, Kása M, Kádár L
Department of Dermatology, County Hospital, Kecskemét, Hungary.
Br J Dermatol. 1989 Jan;120(1):31-6. doi: 10.1111/j.1365-2133.1989.tb07762.x.
Possible early side-effects of retinoid treatment on bones were studied with the aid of bone-scintigraphy. Isotretinoin treatment (1.0 mg/kg daily for 4 months) was given to 18 patients with acne. Fifteen patients with psoriasis received etretinate treatment (0.7-1.0 mg/kg/day) for 4 months. In the group treated with isotretinoin, pathological uptake of radiolabel was found in three cases, while in the group treated with etretinate, no bone changes attributable to treatment were found. During isotretinoin treatment, a decrease in growth-plate activity was observed. Bone-scintigraphy is considered to be a suitable method for early screening for bone changes occurring in retinoid treatment.
借助骨闪烁扫描术研究了维甲酸治疗对骨骼可能产生的早期副作用。对18名痤疮患者给予异维甲酸治疗（每日1.0毫克/千克，持续4个月）。15名银屑病患者接受依曲替酯治疗（0.7 - 1.0毫克/千克/天），持续4个月。在接受异维甲酸治疗的组中，3例发现放射性标记的病理性摄取，而在接受依曲替酯治疗的组中，未发现归因于治疗的骨骼变化。在异维甲酸治疗期间，观察到生长板活性降低。骨闪烁扫描术被认为是早期筛查维甲酸治疗中出现的骨骼变化的合适方法。
