Department of Pulmonology, Semmelweis University , Budapest , Hungary.
Clin Exp Hypertens. 2015;37(4):340-4. doi: 10.3109/10641963.2014.972561. Epub 2014 Oct 27.
A protective role of vascular endothelial growth factor (VEGF) on right heart function has been reported only in animal studies of pulmonary hypertension. Twenty patients with idiopathic pulmonary hypertension and fifteen healthy volunteers were involved. Plasma VEGF levels were compared to right heart parameters. Plasma VEGF levels tended to be higher in patients (82/0-345/pg/ml) than in controls (48/0-141/pg/ml, p = 0.08) with a significant correlation between VEGF concentration and tricuspid annular plane systolic excursion (TAPSE; p = 0.03, r = 0.48). This is the first study to report a positive association between elevated plasma VEGF levels and right heart function in humans.
已有研究报道血管内皮生长因子（VEGF）对右心功能具有保护作用，但仅限于肺动脉高压的动物研究。本研究共纳入 20 例特发性肺动脉高压患者和 15 名健康志愿者。比较了血浆 VEGF 水平与右心参数。患者的血浆 VEGF 水平（82/0-345/pg/ml）高于对照组（48/0-141/pg/ml，p=0.08），且 VEGF 浓度与三尖瓣环平面收缩期位移（TAPSE）呈显著正相关（p=0.03，r=0.48）。这是第一项报道人类血浆 VEGF 水平升高与右心功能之间存在正相关的研究。
