Zimecki M, Wieczorek Z
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Arch Immunol Ther Exp (Warsz). 1989;37(3-4):331-8.
In this report we demonstrated that recombinant human interleukin 1 alpha (Il-1) can directly promote generation of helper cells in the humoral immune response to SRBC in vitro from their intrathymic precursors. Using negative elimination of thymocytes by means of monoclonal antibodies directed against thymocyte antigens L3T4, lyt 2 and CD3 with complement, we showed that Il-1 interacted with L3T4-, lyt 2-, CD3- T cell precursors. We found, in addition, that recombinant Il-1 induced in these cells expression of L3T4, lyt 2, CD3 and T cell receptor (TCR). The results presented in this communication are compatible with the view that Il-1 is responsible for the recruitment of functional T cells in the afferent phase of the immune response.
在本报告中，我们证明重组人白细胞介素1α（Il-1）能直接促进体外对绵羊红细胞（SRBC）的体液免疫应答中辅助细胞从其胸腺内前体细胞的生成。通过用针对胸腺细胞抗原L3T4、lyt 2和CD3的单克隆抗体与补体对胸腺细胞进行阴性清除，我们表明Il-1与L3T4-、lyt 2-、CD3-T细胞前体细胞相互作用。此外，我们发现重组Il-1在这些细胞中诱导L3T4、lyt 2、CD3和T细胞受体（TCR）的表达。本通讯中呈现的结果与以下观点一致，即Il-1在免疫应答的传入阶段负责功能性T细胞的募集。
