Quintana Francisco J, Pérez-Sánchez Soledad, Farez Mauricio F
Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA. E-mail:
Medicina (B Aires). 2014;74(5):404-10.
Multiple sclerosis is an inflammatory demyelinating disease affecting the central nervous system and considered one of the leading causes of disability in young adults. The precise cause of multiple sclerosis is unknown, although the current evidence points towards a combination of genetic and environmental factors leading to an autoimmune response that promotes neuronal degeneration. In this review, we will describe the association between the immune response and neurodegeneration in multiple sclerosis.
多发性硬化症是一种影响中枢神经系统的炎性脱髓鞘疾病，被认为是年轻成年人残疾的主要原因之一。尽管目前的证据表明遗传和环境因素共同作用导致自身免疫反应，进而促进神经元变性，但多发性硬化症的确切病因尚不清楚。在这篇综述中，我们将描述多发性硬化症中免疫反应与神经变性之间的关联。
