子宫颈HPV阴性胃型腺癌的诊断
Diagnosis of HPV-negative, gastric-type adenocarcinoma of the endocervix.
作者信息
Pirog Edyta C
机构信息
Department of Pathology, Weill Medical College of Cornell University, 525 E 68th Street, ST-1041, New York, NY, 10065, USA,
出版信息
Methods Mol Biol. 2015;1249:213-9. doi: 10.1007/978-1-4939-2013-6_16.
Gastric-type adenocarcinoma of the cervix (GAS) is a novel, recently described subtype of endocervical adenocarcinoma. The clinical importance of accurate diagnosis of GAS stems from the observation that it confers worse prognosis than the usual-type endocervical adenocarcinoma. There are two unique characteristics of GAS: the tumor cells contain voluminous amounts of gastric-type mucins, and the tumor pathogenesis is not related to infection with high-risk human papillomavirus types. The histopathologic diagnosis of GAS is difficult; however, it may be confirmed by demonstration of intra-cytoplasmic gastric-type mucins using immunohistochemical staining with monoclonal antibody HIK1083. A protocol for HIK1083 immunostaining is described.
宫颈胃型腺癌（GAS）是一种新的、最近才被描述的宫颈内膜腺癌亚型。准确诊断GAS的临床重要性源于这样的观察结果：与普通型宫颈内膜腺癌相比，它的预后更差。GAS有两个独特特征：肿瘤细胞含有大量胃型黏液，且肿瘤发病机制与高危型人乳头瘤病毒感染无关。GAS的组织病理学诊断很困难；然而，使用单克隆抗体HIK1083进行免疫组化染色，通过显示胞浆内胃型黏液可确诊。本文描述了HIK1083免疫染色的方案。
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