Xing Biyuan, Guo Jianfeng, Sheng Yuhan, Wu Gang, Zhao Yingchao
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2021 Feb 17;10:606335. doi: 10.3389/fonc.2020.606335. eCollection 2020.
Human papillomavirus (HPV) has been the leading cause of cervical cancer for over 25 years. Approximately 5.5-11% of all cervical cancers are reported to be HPV-negative, which can be attributed to truly negative and false-negative results. The truly HPV-negative cervical cancers are almost all cervical adenocarcinomas with unclear etiology. False HPV negativity can arise from histological misclassification, latent HPV infection, disruption of the targeting fragment, non-high risk HPV infection, and HPV testing methods. HPV-negative cervical cancers are often diagnosed at an advanced FIGO stage and have a poor prognosis; thus, the management of these cases requires greater attention.
25 多年来，人乳头瘤病毒（HPV）一直是宫颈癌的主要病因。据报道，所有宫颈癌中约有5.5%-11%为HPV阴性，这可能归因于真正的阴性结果和假阴性结果。真正的HPV阴性宫颈癌几乎都是病因不明的宫颈腺癌。HPV假阴性可能源于组织学误诊、潜伏性HPV感染、靶向片段破坏、非高危型HPV感染以及HPV检测方法。HPV阴性宫颈癌通常在国际妇产科联盟（FIGO）晚期被诊断出来，预后较差；因此，这些病例的管理需要更多关注。
