Wei Xiao-Hong, Wang Gang-Wei, Yang Shang-Dong
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Chem Commun (Camb). 2015 Jan 18;51(5):832-5. doi: 10.1039/c4cc07361d. Epub 2014 Oct 28.
A new method for the synthesis of chiral α-amino acid derivatives by enantioselective C-H arylation of N-aryl glycine esters with aryl boric acids in the presence of a chiral Pd(II)-catalyst has been developed. This work successfully integrates the direct C-H oxidation with asymmetric arylation and exhibits excellent enantioselectivity.
已开发出一种在手性钯（II）催化剂存在下，通过芳基硼酸对N-芳基甘氨酸酯进行对映选择性C-H芳基化反应来合成手性α-氨基酸衍生物的新方法。这项工作成功地将直接C-H氧化与不对称芳基化相结合，并表现出优异的对映选择性。
