污染的洗手池作为血液科病房产KPC-2肺炎克雷伯菌克隆暴发的源头。
Contaminated handwashing sinks as the source of a clonal outbreak of KPC-2-producing Klebsiella oxytoca on a hematology ward.
作者信息
Leitner Eva, Zarfel Gernot, Luxner Josefa, Herzog Kathrin, Pekard-Amenitsch Shiva, Hoenigl Martin, Valentin Thomas, Feierl Gebhard, Grisold Andrea J, Högenauer Christoph, Sill Heinz, Krause Robert, Zollner-Schwetz Ines
机构信息
Institute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
出版信息
Antimicrob Agents Chemother. 2015 Jan;59(1):714-6. doi: 10.1128/AAC.04306-14. Epub 2014 Oct 27.
Abstract
We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase (KPC)-producing Klebsiella oxytoca outbreak. Seven carbapenem-resistant K. oxytoca isolates were identified in sink drains in 4 patient rooms and in the medication room. Investigations for resistance genes and genetic relatedness of patient and environmental isolates revealed that all the isolates harbored the blaKPC-2 and blaTEM-1 genes and were genetically indistinguishable. We describe here a clonal outbreak caused by KPC-2-producing K. oxytoca, and handwashing sinks were a possible reservoir.
摘要
我们调查了水槽，其可能是产肺炎克雷伯菌碳青霉烯酶（KPC）的产酸克雷伯菌长时间暴发的来源。在4间病房的水槽排水口和配药室中鉴定出7株耐碳青霉烯类产酸克雷伯菌分离株。对患者和环境分离株的耐药基因及基因相关性进行调查发现，所有分离株均携带blaKPC - 2和blaTEM - 1基因，且在基因上无法区分。我们在此描述了由产KPC - 2的产酸克雷伯菌引起的克隆性暴发，洗手水槽可能是一个储存宿主。
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