Masekela R, Anderson R, de Boeck K, Vreys M, Steel H C, Olurunju S, Green R J
Division of Pulmonology, Department of Paediatrics and Child Health, Steve Biko Academic Hospital, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Pediatr Pulmonol. 2015 Apr;50(4):333-9. doi: 10.1002/ppul.23121. Epub 2014 Oct 27.
Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is demonstrating promise as an inflammatory biomarker of acute infection in various pulmonary conditions; including community acquired pneumonia, ventilator associated pneumonia and non-tuberculous mycobacterial infection.
The expression of sTREM-1 has been poorly studied in all forms of bronchiectasis, both in the context of cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis.
Induced sputum samples were collected for sTREM-1 determination in children with HIV-associated bronchiectasis and CF-bronchiectasis. The presence or absence of an exacerbation was noted at study entry. Lung function parameters (FEV1, FVC, FEV1 /FVC, FEF(25-75)) were measured using the Viasys SpiroPro Jaeger Spirometer (Hoechberg, Germany).
A total of twenty-six children with HIV-associated bronchiectasis and seventeen with CF were included. With respect to sTREM-1, the levels were readily detected in both groups, but were significantly higher in children with HIV-associated bronchiectasis (1244.0 pg/ml (iqr 194.5; 3755.3 pg/ml) and 204.9 pg/ml (iqr 66.9; 653.6 pg/ml) P = 0.003. There was a positive correlation between sTREM-1 and IL-8 as well as sputum neutrophil elastase in the HIV-bronchiectasis group (r = 0.715 and r = 0.630), respectively both P < 0.005. sTREM-1 was not further increased in subjects presenting with an acute pulmonary exacerbation in the HIV-associated bronchiectasis and in CF participants (P = 0.971 and P = 0.481), respectively. In the CF group sTREM-1 strongly correlated with FVC% predicted and FEV1 % predicted (r = 0.950 and r = 0.954), both P < 0.005.
The pulmonary innate immune functions are over-active in HIV-associated bronchiectasis, with readily detected sTREM-1 values, which were higher than those in CF. sTREM-1 does not correlate with markers of HIV-disease activity but does correlate with markers of neutrophilic inflammation. In CF sTREM-1 has a negative correlation with pulmonary function parameters.
髓系细胞触发受体-1（sTREM-1）作为各种肺部疾病（包括社区获得性肺炎、呼吸机相关性肺炎和非结核分枝杆菌感染）急性感染的炎症生物标志物显示出应用前景。
sTREM-1在所有形式的支气管扩张症（包括囊性纤维化（CF）和非囊性纤维化支气管扩张症）中的表达研究较少。
收集感染人类免疫缺陷病毒（HIV）相关支气管扩张症和CF支气管扩张症患儿的诱导痰样本以测定sTREM-1。研究开始时记录是否存在病情加重。使用Viasys SpiroPro耶格肺功能仪（德国赫希贝格）测量肺功能参数（第一秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC、25%-75%用力呼气流量（FEF(25-75)））。
共纳入26例HIV相关支气管扩张症患儿和17例CF患儿。关于sTREM-1，两组均易于检测到其水平，但HIV相关支气管扩张症患儿的水平显著更高（分别为1244.0 pg/ml（四分位间距194.5；3755.3 pg/ml）和204.9 pg/ml（四分位间距66.9；653.6 pg/ml），P = 0.003）。在HIV支气管扩张症组中，sTREM-1与白细胞介素-8以及痰液中性粒细胞弹性蛋白酶呈正相关（r分别为0.715和0.630），P均<0.005。在HIV相关支气管扩张症和CF参与者中，出现急性肺部病情加重的受试者的sTREM-1没有进一步升高（分别为P = 0.971和P = 0.481）。在CF组中，sTREM-1与预测的FVC%和预测的FEV1%密切相关（r分别为0.950和0.954），P均<0.005。
HIV相关支气管扩张症中肺部固有免疫功能过度活跃，sTREM-1值易于检测到，且高于CF中的值。sTREM-1与HIV疾病活动标志物无关，但与中性粒细胞炎症标志物相关。在CF中，sTREM-1与肺功能参数呈负相关。
