无多巴胺能缺陷证据的扫描患者：一项长期随访研究。
Patients with scans without evidence of dopaminergic deficit: a long-term follow-up study.
作者信息
Batla Amit, Erro Roberto, Stamelou Maria, Schneider Susanne A, Schwingenschuh Petra, Ganos Christos, Bhatia Kailash P
机构信息
Sobell Department of Motor Neuroscience and Movement disorders, UCL Institute of Neurology, London, United Kingdom.
出版信息
Mov Disord. 2014 Dec;29(14):1820-5. doi: 10.1002/mds.26018. Epub 2014 Oct 28.
BACKGROUND
We previously reported on a cohort of dystonic tremor and patients with scans without evidence of dopaminergic deficit (SWEDDs). We aim to report the long-term clinical and imaging follow-up of these patients.
PATIENTS AND METHODS
Patients with at least 5-year follow-up were included. These patients had an asymmetric arm tremor, a previous diagnosis of Parkinson's disease (PD), and a subsequent normal DaTscan. The imaging and clinical follow-up was done on the clinical basis.
RESULTS
Sixteen patients were included. The mean gap between the first and subsequent scans was 5.4 years. Two patients (12.5%) had reduced nigrostriatal uptake on follow-up DaTscan, whereas 14 continued to have normal dopaminergic imaging.
CONCLUSION
This is the longest follow up of patients with asymmetric rest tremor and normal DaT scans (SWEDDs) reported to date. We show here that only a minority of them show reduced striatonigral uptake over long term follow up.
背景
我们之前报道了一组肌张力障碍性震颤患者以及多巴胺能缺陷扫描无证据（SWEDDs）的患者。我们旨在报告这些患者的长期临床和影像学随访情况。
患者与方法
纳入至少随访5年的患者。这些患者有不对称性手臂震颤，既往诊断为帕金森病（PD），且随后DaTscan检查结果正常。影像学和临床随访均基于临床进行。
结果
纳入16例患者。首次扫描与后续扫描之间的平均间隔时间为5.4年。2例患者（12.5%）在随访DaTscan检查时黑质纹状体摄取减少，而14例患者多巴胺能影像学检查结果持续正常。
结论
这是迄今为止报道的对不对称性静止性震颤且DaT扫描正常（SWEDDs）患者最长时间的随访。我们在此表明，在长期随访中，只有少数患者显示纹状体黑质摄取减少。
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