Zhang Yan, Corona-Villalobos Celia P, Kiani Adnan N, Eng John, Kamel Ihab R, Zimmerman Stefan L, Petri Michelle
Shandong Medical Imaging Research Institute, Jinwu Road 324, Jinan, 250021, China,
Int J Cardiovasc Imaging. 2015 Feb;31(2):389-97. doi: 10.1007/s10554-014-0560-3. Epub 2014 Oct 29.
To evaluate whether T2 mapping techniques can detect myocardial edema in patients with systemic lupus erythematosus (SLE). Twenty-four patients (mean age 54 ± 9 years) with SLE and twelve controls (mean age 50 ± 7 years) underwent cardiac MRI at 1.5 T. Standard cine images were obtained. Single-slice T2 maps and non-contrast T1 maps were acquired in a mid-cavity short-axis plane. Late gadolinium enhancement (LGE) images were obtained 15 min after 0.2 mmol/kg of contrast. SLE patients had low disease activity (mean SLE disease activity index score 0.71 ± 0.8). There were no differences in LV size or function between SLE patients and controls. No subjects had LGE. T2 times were higher in SLE patients (58.2 ± 5.6 vs. 52.8 ± 4.4 ms, p = 0.009). On multivariate analysis including demographic and LV parameters, only the diagnosis of SLE was associated with T2 time (p = 0.01). T1 times trended lower in SLE patients, (981.6 ± 65.5 vs. 963.9 ± 32.5), however, differences were not significant (p = 0.3). Repeated measures were highly correlated by linear regression for both inter- and intraobserver analysis (both R = 0.95, p < 0.001). Inter- and intraobserver bias and limits of agreement were -0.4 ± 3.8 and 1.0 ± 3.3 ms, respectively. T2-mapping identifies increased myocardial T2 times in SLE patients, likely due to subclinical myocardial edema. These findings suggest that even in SLE patients with inactive disease and normal cardiac function, low grade myocardial inflammation can be detected by this novel quantitative and highly reproducible technique.
评估T2映射技术能否检测系统性红斑狼疮（SLE）患者的心肌水肿。24例SLE患者（平均年龄54±9岁）和12例对照者（平均年龄50±7岁）接受了1.5T心脏磁共振成像（MRI）检查。获取了标准电影图像。在中腔短轴平面采集单层面T2图和无对比剂T1图。在注射0.2 mmol/kg对比剂15分钟后获取延迟钆增强（LGE）图像。SLE患者疾病活动度低（平均SLE疾病活动指数评分为0.71±0.8）。SLE患者与对照者之间左心室大小或功能无差异。所有受试者均无LGE。SLE患者的T2时间更高（58.2±5.6对52.8±4.4毫秒，p = 0.009）。在包括人口统计学和左心室参数的多变量分析中，仅SLE诊断与T2时间相关（p = 0.01）。SLE患者的T1时间有降低趋势（981.6±65.5对963.9±32.5），但差异无统计学意义（p = 0.3）。对于观察者间和观察者内分析，重复测量通过线性回归具有高度相关性（两者R = 0.95，p < 0.001）。观察者间和观察者内偏差及一致性界限分别为-0.4±3.8和1.0±3.3毫秒。T2映射可识别SLE患者心肌T2时间增加，可能是由于亚临床心肌水肿。这些发现表明，即使在疾病不活动且心功能正常的SLE患者中，这种新型的定量且高度可重复的技术也能检测到轻度心肌炎症。
