Tikkanen T
Unit of Clinical Physiology, Minerva Institute for Medical Research, Helsinki, Finland.
Scand J Clin Lab Invest. 1989 Apr;49(2):113-20. doi: 10.3109/00365518909105408.
In order to study long term changes in plasma atrial natriuretic peptide (ANP) in chronic heart failure, plasma ANP levels were determined in rats after myocardial infarction due to coronary artery ligation and in sham-operated controls. In addition, effects of oral captopril treatment and sodium loading on plasma ANP were studied. In accordance with earlier reports plasma ANP paralleled both infarct size and signs of cardiac dysfunction. The highest plasma ANP levels were found in rats having over 45% of their left ventricle infarcted while rats with mild-to-moderate-size infarcts had only slightly elevated plasma ANP levels as compared with controls. These differences in plasma ANP levels between experimental and control groups remained remarkably stable during the three-month observation period. Plasma renin activity (PRA) was elevated in infarcted rats but no differences could be found between rats with varying infarct sizes. Captopril treatment decreased the high plasma ANP levels in rats with the largest infarcts, probably by unloading the failing heart. During increased sodium intake, plasma ANP levels increased in sham-operated controls but not in rats with heart failure. Thus, sodium loading, as compared with cardiac insufficiency, appears to be a weak stimulus for ANP release in rats. I conclude that plasma ANP is a sensitive marker, better than PRA, in long term follow-up of cardiac dysfunction.
为研究慢性心力衰竭时血浆心钠素（ANP）的长期变化，对冠状动脉结扎致心肌梗死的大鼠及假手术对照组大鼠测定了血浆ANP水平。此外，还研究了口服卡托普利治疗及钠负荷对血浆ANP的影响。与早期报道一致，血浆ANP与梗死面积及心脏功能障碍的体征均平行。左心室梗死超过45%的大鼠血浆ANP水平最高，而轻度至中度梗死面积的大鼠与对照组相比血浆ANP水平仅略有升高。实验组与对照组之间血浆ANP水平的这些差异在三个月的观察期内保持显著稳定。梗死大鼠的血浆肾素活性（PRA）升高，但不同梗死面积的大鼠之间未发现差异。卡托普利治疗降低了梗死面积最大的大鼠的高血浆ANP水平，可能是通过减轻衰竭心脏的负荷。在钠摄入量增加时，假手术对照组的血浆ANP水平升高，而心力衰竭大鼠的血浆ANP水平未升高。因此，与心脏功能不全相比，钠负荷似乎是大鼠ANP释放的较弱刺激因素。我得出结论，在心脏功能障碍的长期随访中，血浆ANP是比PRA更敏感的标志物。
