Iwao H, Fukui K, Yamamoto A, Shoji T, Abe Y
Clin Exp Hypertens A. 1987;9(2-3):697-701. doi: 10.3109/10641968709164245.
We investigated the effects of captopril on the plasma atrial natriuretic polypeptide (ANP) level and the renin angiotensin system in rats. A single oral administration of captopril decreased the plasma ANP level and increased the plasma renin activity (PRA). Chronic administration of captopril for 2 weeks caused no changes in plasma ANP level, but PRA was increased. This suggests the hypothesis that the hemodynamic changes rather than changes in the renin angiotensin system caused by captopril may affect the plasma ANP level.
我们研究了卡托普利对大鼠血浆心钠素（ANP）水平及肾素-血管紧张素系统的影响。单次口服卡托普利可降低血浆ANP水平并增加血浆肾素活性（PRA）。卡托普利连续给药2周对血浆ANP水平无影响，但PRA升高。这提示了一个假说，即卡托普利引起的血流动力学变化而非肾素-血管紧张素系统的变化可能影响血浆ANP水平。
