Abd El-Kader Shehab M, Al-Jiffri Osama H, Al-Shreef Fadwa M
Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
Afr Health Sci. 2014 Sep;14(3):551-7. doi: 10.4314/ahs.v14i3.8.
Non-alcoholic steatohepatitis is a growing public health problem with no approved therapy; as cytokines and other pro-inflammatory mediators may each play a role in transition of steatosis to NASH which is projected to be the leading cause of liver transplantation in the United States by 2020.
The aim of this study was to compare the impact of aerobic versus resisted exercise training on inflammatory cytokines and markers of liver function in patients with nonalcoholic steatohepatitis.
Fifty patients with NASH were included in the study and divided into two subgroups. Participants were included into 2 equal groups; the first group (A) received aerobic exercise training. The second group (B) received resisted exercise training three times a week for 3 months.
The mean values of TNF- α, IL6, IL8, ALT and AST were significantly decreased in group (A) and group (B). Also; there was a significant difference between both groups after treatment.
Aerobic exercise training modulates inflammatory cytokine levels and markers of liver function in patients with nonalcoholic steatohepatitis.
非酒精性脂肪性肝炎是一个日益严重的公共卫生问题，目前尚无获批的治疗方法；细胞因子和其他促炎介质可能在脂肪变性向非酒精性脂肪性肝炎的转变中均发挥作用，预计到2020年非酒精性脂肪性肝炎将成为美国肝移植的主要原因。
本研究旨在比较有氧运动训练与抗阻运动训练对非酒精性脂肪性肝炎患者炎症细胞因子和肝功能指标的影响。
50例非酒精性脂肪性肝炎患者纳入本研究并分为两个亚组。参与者被分为两组，每组人数相等；第一组（A组）接受有氧运动训练。第二组（B组）每周接受3次抗阻运动训练，共3个月。
A组和B组的肿瘤坏死因子-α、白细胞介素6、白细胞介素8、谷丙转氨酶和谷草转氨酶的平均值均显著降低。此外，治疗后两组之间存在显著差异。
有氧运动训练可调节非酒精性脂肪性肝炎患者的炎症细胞因子水平和肝功能指标。
