Fatih University Medical Faculty, Department of Biochemistry, Turkey.
Clin Biochem. 2011 Dec;44(17-18):1375-9. doi: 10.1016/j.clinbiochem.2011.09.017. Epub 2011 Oct 8.
The relation between nonalcoholic steatohepatitis and iron metabolism is still controversial. Free fatty acids, iron, and other sources of oxidative stress probably result in cell damage, and necroinflammation mediated by various cytokines.
Sixty patients were diagnosed with NASH were included in the study, and the patient group was divided into three subgroups. Iron metabolism markers, inflammatory cytokines, including TNF-α, IL-6 and IL-8, MDA and nitric oxide levels were measured.
Serum ferritin, inflammatory cytokines, and oxidative stress markers were significantly higher in the patient group. Among three patient groups, divided according to the results of ultrasonic examination, there were significant changes with regard to these parameters.
The study results suggest that liver iron and fat accumulation, oxidant stres, and inflammatory cytokines are closely related. Therefore, levels of serum ferritin, MDA, IL-6, TNF-α and IL-8 could represent the indices of activity and progression of NASH.
非酒精性脂肪性肝炎与铁代谢之间的关系仍存在争议。游离脂肪酸、铁和其他来源的氧化应激可能导致细胞损伤，并由各种细胞因子介导的坏死性炎症。
本研究纳入了 60 例被诊断为 NASH 的患者，并将患者分为三组。测量铁代谢标志物、炎症细胞因子（TNF-α、IL-6 和 IL-8）、MDA 和一氧化氮水平。
患者组的血清铁蛋白、炎症细胞因子和氧化应激标志物明显升高。根据超声检查结果将三组患者进行分组，这些参数也有显著变化。
研究结果表明，肝脏铁和脂肪堆积、氧化应激和炎症细胞因子密切相关。因此，血清铁蛋白、MDA、IL-6、TNF-α 和 IL-8 水平可以代表 NASH 的活动和进展的指标。
