Vázquez-López María A, Ibáñez-Alcalde Mercedes, Lendínez-Molinos Francisco, Ruíz-Sánchez Ana M, Galera-Martínez Rafael, García-García Emilio, Parrón-Carreño Tesifón, Bonillo-Perales Antonio
Department of Pediatrics, Torrecárdenas Hospital, Almería, Spain.
J Pediatr Hematol Oncol. 2015 May;37(4):274-80. doi: 10.1097/MPH.0000000000000274.
Adolescence is a period of increased iron requirements, which impact on iron status. The purpose of this research is to determine the reference intervals for serum transferrin receptor (sTfR) and sTfR/log ferritin index (sTfR-F index) in healthy adolescents, and their relation with iron parameters and erythropoiesis. A total of 253 healthy adolescents without overweight, aged 12 to 16 years, were selected in a cross-sectional study. Hemoglobin, red cell indices, reticulocyte hemoglobin content (rHb), reticulocytes, ferritin, transferrin saturation, erythrocyte protoporphirin, erythropoietin, C-reactive protein, sTfR, and sTfR-F index were measured. Changes in erythropoiesis and iron status in the age interval were observed and analyzed, and linear multiple regression was applied to identify the factors that determine the variability of sTfR and sTfR-F index. Mean values for sTfR and sTfR-F index were 1.32 ± 0.3 mg/L (95% CI, 1.3-1.36) and 0.9 ± 0.25 (95% CI, 0.87-0.93). The reference intervals were 0.84 to 1.97 mg/L and 0.51 to 1.44, respectively. sTfR and sTfR-F index values were significantly higher in boys (1.39 ± 0.3 vs. 1.23 ± 0.26 mg/L, P<0.0001 and 0.93 ± 0.37 vs. 0.86 ± 0.22, P<0.04) and decreased with age (P<0.0001 and 0.04, respectively). No changes were recorded in erythropoietin. Age, sex, pubertal status, and ferritin predicted 24.1% of sTfR variability and age, sex, pubertal status, transferrin saturation, rHb, erythrocytes, and reticulocytes predicted 15% of sTfR-F index variability.
青春期是铁需求量增加的时期，这会影响铁状态。本研究的目的是确定健康青少年血清转铁蛋白受体（sTfR）和sTfR/铁蛋白对数指数（sTfR-F指数）的参考区间，以及它们与铁参数和红细胞生成的关系。在一项横断面研究中，共选取了253名年龄在12至16岁、无超重的健康青少年。测量了血红蛋白、红细胞指数、网织红细胞血红蛋白含量（rHb）、网织红细胞、铁蛋白、转铁蛋白饱和度、红细胞原卟啉、促红细胞生成素、C反应蛋白、sTfR和sTfR-F指数。观察并分析了该年龄区间内红细胞生成和铁状态的变化，并应用线性多元回归来确定决定sTfR和sTfR-F指数变异性的因素。sTfR和sTfR-F指数的平均值分别为1.32±0.3mg/L（95%CI，1.3 - 1.36）和0.9±0.25（95%CI，0.87 - 0.93）。参考区间分别为0.84至1.97mg/L和0.51至1.44。男孩的sTfR和sTfR-F指数值显著更高（1.39±0.3对1.23±0.26mg/L，P<0.0001；0.93±0.37对0.86±0.22，P<0.04），且随年龄下降（分别为P<0.0001和0.04）。促红细胞生成素未发现变化。年龄、性别、青春期状态和铁蛋白可预测sTfR变异性的24.1%，年龄、性别、青春期状态、转铁蛋白饱和度、rHb、红细胞和网织红细胞可预测sTfR-F指数变异性的15%。
