可溶性糖蛋白（sGP）在埃博拉病毒发病机制中的多重作用。
The multiple roles of sGP in Ebola pathogenesis.
作者信息
de La Vega Marc-Antoine, Wong Gary, Kobinger Gary P, Qiu Xiangguo
机构信息
1 Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada , Winnipeg, Manitoba, Canada .
出版信息
Viral Immunol. 2015 Feb;28(1):3-9. doi: 10.1089/vim.2014.0068.
Abstract
Ebola causes severe hemorrhagic fever in humans and nonhuman primates, and there are currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) may be partially attributed to the secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. sGP is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments.
摘要
埃博拉病毒可导致人类和非人类灵长类动物患上严重的出血热，目前尚无获批的治疗对策。埃博拉病毒（EBOV）的毒力可能部分归因于分泌型糖蛋白（sGP），它是EBOV的GP基因转录产生的主要产物。sGP从受感染细胞中分泌出来，在感染EBOV的宿主血清中很容易检测到。本文综述了sGP在感染过程中可能发挥的多种作用，并强调了其对未来疫苗和治疗设计的启示。
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