Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
Mol Neurobiol. 2015 Dec;52(3):1477-1493. doi: 10.1007/s12035-014-8958-4. Epub 2014 Oct 30.
Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and memory storage in hippocampus. However, changes of BDNF level and expression have been reported in the CNS as well as blood of Alzheimer's disease (AD) patients in the last decade, which indicates a potential role of BDNF in the pathogenesis of AD. Therefore, this review aims to summarize the latest progress in the field of BDNF and its biological roles in AD pathogenesis. We will discuss the interaction between BDNF and amyloid beta (Aβ) peptide, the effect of BDNF on synaptic repair in AD, and the association between BDNF polymorphism and AD risk. The most important is, enlightening the detailed biological ability and complicated mechanisms of action of BDNF in the context of AD would provide a future BDNF-related remedy for AD, such as increment in the production or release of endogenous BDNF by some drugs or BDNF mimics.
脑源性神经营养因子（BDNF）对中枢神经系统（CNS）的神经元具有神经营养支持作用，是维持海马体突触可塑性和记忆储存的关键分子。然而，在过去十年中，AD 患者的中枢神经系统和血液中都报告了 BDNF 水平和表达的变化，这表明 BDNF 在 AD 的发病机制中具有潜在作用。因此，本综述旨在总结 BDNF 及其在 AD 发病机制中的生物学作用的最新进展。我们将讨论 BDNF 与淀粉样β（Aβ）肽的相互作用、BDNF 对 AD 中突触修复的影响以及 BDNF 多态性与 AD 风险之间的关系。最重要的是，阐明 BDNF 在 AD 背景下的详细生物学能力和复杂作用机制，将为 AD 提供未来的 BDNF 相关治疗方法，例如通过某些药物或 BDNF 模拟物增加内源性 BDNF 的产生或释放。
