Fu Xiaodan, Ma Xiangyu, Zhong Li, Song Zhiyuan
Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
College of Preventive Medicine, Third Military Medical University, Chongqing, China.
J Renin Angiotensin Aldosterone Syst. 2015 Mar;16(1):185-8. doi: 10.1177/1470320314553984. Epub 2014 Oct 29.
The aldosterone synthase (CYP11B2)-344T>C gene polymorphism has been reported to influence the risk of atrial fibrillation (AF) in many studies; however, the results remain controversial and ambiguous.
We therefore carried out a meta-analysis of published case-control studies to investigate the association between CYP11B2-344T>C polymorphism and AF susceptibility. Electronic searches were conducted on links between this variant and AF in several databases. Odds ratios (ORs) and 95% confidence intervals (CIs) for homozygous, dominant model, recessive model and allele were calculated to estimate the strength of associations in fixed and random effect models. Heterogeneity and publication bias were also assessed.
A total of nine case-control studies were identified. The C allele was associated with an increased susceptibility risk of AF compared with the T allele among hypertension populations (OR=1.26; 95% CI=1.09-1.45). The contrast of homozygotes and the recessive model produced the same pattern of results as the allele contrast. In the hypertension population, a significant association was found for the genetic models that were examined.
Our pooled data suggest a significant association exists between CYP11B2-344T>C polymorphism and AF among hypertension populations.
许多研究报道醛固酮合酶（CYP11B2）-344T>C基因多态性会影响心房颤动（AF）的风险；然而，结果仍存在争议且不明确。
因此，我们对已发表的病例对照研究进行了荟萃分析，以探讨CYP11B2-344T>C多态性与AF易感性之间的关联。在几个数据库中对该变异与AF之间的联系进行了电子检索。计算了纯合子、显性模型、隐性模型和等位基因的优势比（OR）和95%置信区间（CI），以估计固定效应模型和随机效应模型中的关联强度。还评估了异质性和发表偏倚。
共确定了9项病例对照研究。在高血压人群中，与T等位基因相比，C等位基因与AF易感性风险增加相关（OR=1.26；95%CI=1.09-1.45）。纯合子对比和隐性模型产生了与等位基因对比相同的结果模式。在高血压人群中，所检测的遗传模型存在显著关联。
我们的汇总数据表明，在高血压人群中，CYP11B2-344T>C多态性与AF之间存在显著关联。
