Sun Shuang, Zhao Yan, Jin Guojiang, Kang Hui
Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Neurol Sci. 2014 Dec;35(12):1867-76. doi: 10.1007/s10072-014-1973-4. Epub 2014 Oct 30.
Although many case-control studies have investigated the association between a single UCHL1 S18Y gene polymorphism and the risk of Parkinson's disease (PD), the results have been ambiguous. To evaluate the overall effect between published case-control studies of Asian subjects, we conducted a meta-analysis based on 11 studies including 3,971 PD cases and 3,721 controls. Studies carried out up to 30 April 2014, were identified using the databases PubMed, MEDLINE, EMBASE and Web of Knowledge. The crude odds ratios (ORs) with 95 % confidence intervals (95 % CI) were calculated to evaluate the association. The results of our meta-analysis indicated that the UCHL1 S18Y gene polymorphism does not correlate with the risk of PD (allele model: OR 0.93, 95 % CI 0.84-1.02; dominant model: OR 0.94, 95 % CI 0.86-1.04; recessive model: OR 0.90, 95 % CI 0.77-1.06; homozygous model: OR 0.86, 95 % CI 0.71-1.04). A similar result was observed in subgroup analysis of ethnicity, age at onset, genotype methods, Hardy-Weinberg equilibrium, and source of controls. Thus, the current meta-analysis suggests no evidence for the association between the UCHL1 S18Y polymorphism and PD risk in the Asian population, especially in subgroups of ethnicity and age at onset. Further studies with larger population sizes are needed to confirm this result.
尽管许多病例对照研究调查了单个UCHL1 S18Y基因多态性与帕金森病（PD）风险之间的关联，但其结果一直不明确。为了评估已发表的亚洲受试者病例对照研究之间的总体效应，我们基于11项研究进行了荟萃分析，其中包括3971例PD病例和3721例对照。利用PubMed、MEDLINE、EMBASE和Web of Knowledge数据库检索截至2014年4月30日开展的研究。计算粗比值比（OR）及其95%置信区间（95%CI）以评估这种关联。我们的荟萃分析结果表明，UCHL1 S18Y基因多态性与PD风险无关（等位基因模型：OR 0.93，95%CI 0.84 - 1.02；显性模型：OR 0.94，95%CI 0.86 - 1.04；隐性模型：OR 0.90，95%CI 0.77 - 1.06；纯合子模型：OR 0.86，95%CI 0.71 - 1.04）。在种族、发病年龄、基因分型方法、哈迪-温伯格平衡和对照来源的亚组分析中观察到了类似结果。因此，当前的荟萃分析表明，在亚洲人群中，尤其是在种族和发病年龄亚组中，没有证据支持UCHL1 S18Y多态性与PD风险之间存在关联。需要进一步开展更大样本量的研究来证实这一结果。
