Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Neurodegener Dis. 2014;14(4):194-203. doi: 10.1159/000367995. Epub 2014 Dec 2.
The ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene has been implicated in the etiology of Parkinson's disease (PD). Several studies have evaluated the association between the UCH-L1 S18Y variant and the risk of PD. However, conflicting results have been reported. Therefore, we performed a meta-analysis to explore whether the UCH-L1 S18Y variant is associated with susceptibility to PD in Asians. A database search in Web of Science, MEDLINE, Embase and PubMed up to March 2014 identified 10 studies comprising 4,897 PD patients and 4,446 controls in total, which were included in this meta-analysis. In an updated meta-analysis, no significant associations between the S18Y polymorphism and PD in Asians were observed in recessive [p = 0.28, odds ratio (OR) = 1.47, 95% confidence interval (CI): 0.86-1.04] or dominant models (p = 0.46, OR = 0.96, 95% CI: 0.88-1.06). In the subgroup analysis by ethnicity, still no significant association was detected in dominant (for Chinese, OR = 0.97, 95% CI: 0.85-1.10; for Japanese, OR = 0.96, 95% CI: 0.83-1.11) and recessive models (for Chinese, OR = 0.99, 95% CI: 0.88-1.11; for Japanese, OR = 0.89, 95% CI: 0.76-1.04). The results of this meta-analysis suggested that the UCHL-1 S18Y polymorphism was not associated with the risk of PD in Asians. To our knowledge, this is the latest and largest meta-analysis assessing the association of the UCHL-1 S18Y variant with the risk of PD in Asian ancestry. © 2014 S. Karger AG, Basel.
泛素羧基末端水解酶 L1（UCH-L1）基因与帕金森病（PD）的发病机制有关。几项研究评估了 UCH-L1 S18Y 变体与 PD 风险之间的关联。然而，报道的结果存在冲突。因此，我们进行了荟萃分析，以探讨 UCH-L1 S18Y 变体是否与亚洲人患 PD 的易感性相关。在 2014 年 3 月之前，通过 Web of Science、MEDLINE、Embase 和 PubMed 数据库搜索，共确定了 10 项研究，共纳入 4897 例 PD 患者和 4446 例对照，这些研究被纳入本荟萃分析。在更新的荟萃分析中，在亚洲人群中，隐性模型 [p = 0.28，优势比（OR）= 1.47，95%置信区间（CI）：0.86-1.04]或显性模型（p = 0.46，OR = 0.96，95%CI：0.88-1.06）中，S18Y 多态性与 PD 之间均无显著相关性。按种族亚组分析，显性模型（对于中国人，OR = 0.97，95%CI：0.85-1.10；对于日本人，OR = 0.96，95%CI：0.83-1.11）和隐性模型（对于中国人，OR = 0.99，95%CI：0.88-1.11；对于日本人，OR = 0.89，95%CI：0.76-1.04）中也未发现显著相关性。本荟萃分析的结果表明，UCHL-1 S18Y 多态性与亚洲人患 PD 的风险无关。据我们所知，这是评估 UCHL-1 S18Y 变体与亚洲人 PD 风险关联的最新、最大的荟萃分析。© 2014 S. Karger AG，巴塞尔。
