培养皿中的神经退行性疾病：诱导多能干细胞技术在疾病建模和治疗发现中的前景
Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery.
作者信息
Xie Y Z, Zhang R X
机构信息
Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan Province, China,
出版信息
Neurol Sci. 2015 Jan;36(1):21-7. doi: 10.1007/s10072-014-1989-9. Epub 2014 Oct 30.
Abstract
The study of stem-cell biology has been a flourishing research area because of its multi-differentiation potential. The emergence of induced pluripotent stem cells (iPSCs) open up the possibility of addressing obstructs, such as the limited cell source, inherent complexity of the human brain, and ethical constrains. Though still at its infancy phase, reprogramming of somatic cells has been demonstrating the ability to enhance in vitro study of neurodegenerative diseases and potential treatment. However, iPSCs would not thoroughly translate to the clinic before limitations are addressed. In this review, by summarizing the recent development of iPSC-based models, we will discuss the feasibility of iPSC technology on relevant diseases depth and illustrate how this new tool applies to drug screening and celluar therapy.
摘要
由于干细胞生物学具有多分化潜能，它一直是一个蓬勃发展的研究领域。诱导多能干细胞（iPSC）的出现为解决诸如细胞来源有限、人类大脑固有的复杂性以及伦理限制等障碍开辟了可能性。尽管体细胞重编程仍处于起步阶段，但它已显示出增强神经退行性疾病体外研究及潜在治疗的能力。然而，在解决局限性之前，iPSC尚无法完全应用于临床。在本综述中，通过总结基于iPSC模型的最新进展，我们将深入探讨iPSC技术在相关疾病上的可行性，并阐明这种新工具如何应用于药物筛选和细胞治疗。
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