Fukumoto Seiji
Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital, Japan.
Clin Calcium. 2014 Nov;24(11):1701-5.
Teriparatide is a peptide with 34 amino acids that corresponds to N-terminal portion of parathyroid hormone (PTH) . Teriparatide is the only anabolic agent currently available and prevent fractures by increasing bone mass and improving bone architecture. PTH and bone turnover are reported to be low in some patients with type 2 diabetes and chronic kidney disease. For these patients, it seems to be theoretically reasonable to use teriparatide. However, it has not been shown that teriparatide is more effective for patients with low bone turnover than other subjects.
特立帕肽是一种由34个氨基酸组成的肽，相当于甲状旁腺激素（PTH）的N端部分。特立帕肽是目前唯一可用的促合成代谢药物，通过增加骨量和改善骨结构来预防骨折。据报道，一些2型糖尿病和慢性肾病患者的PTH和骨转换率较低。对于这些患者，使用特立帕肽在理论上似乎是合理的。然而，尚未证明特立帕肽对骨转换率低的患者比其他受试者更有效。
