Cai Ting, Yuan Wei
Department of Otorhinolaryngology-Head and Neck Surgery, Southwest Hospital of the Third Military Medical University, Chongqing 400038, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Oct;39(10):1088-92. doi: 10.11817/j.issn.1672-7347.2014.10.018.
As the basic physiological function of synapses, vesicle cycling involves in many aspects of process. Among them, vesicle recycling is the basis of synaptic vesicle cycling. Studies show that clathrin mediated endocytosis is a major pathway of vesicle recycling, in which Dynamin plays an important role. Dynamin is a GTPases with molecular weight of 100 kD, which acts as "scissors" in the endocytosis, separating the clathrin coated pits from membrane. It has been found that Dynamin is associated with epilepsy, Alzheimer's disease, centronuclear myopathy, and several other neurological diseases. In this paper, we discussed the structure, function and regulation of Dynamin, and reviewed recent advance in the studies on Dynamin related diseases.
作为突触的基本生理功能，囊泡循环涉及多个过程。其中，囊泡再循环是突触囊泡循环的基础。研究表明，网格蛋白介导的内吞作用是囊泡再循环的主要途径，动力蛋白在其中发挥重要作用。动力蛋白是一种分子量为100 kD的GTP酶，在内吞作用中充当“剪刀”，将网格蛋白包被小窝与细胞膜分离。已发现动力蛋白与癫痫、阿尔茨海默病、中央核性肌病以及其他几种神经疾病有关。本文讨论了动力蛋白的结构、功能和调节，并综述了动力蛋白相关疾病研究的最新进展。
