Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine.
作者信息
Murakami Yuko, Suzuki Rina, Yanuma Hiroto, He Jiangtao, Ma Shuren, Turino Gerard M, Lin Yong Y, Usuki Toyonobu
机构信息
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
出版信息
Org Biomol Chem. 2014 Dec 28;12(48):9887-94. doi: 10.1039/c4ob01438c.
PMID:25355397
Abstract
Desmosine-CH2, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH2 was also achieved.
摘要
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