[(13)C3,(15)N1]标记的异锁链素：弹性蛋白降解中锁链素LC-MS/MS分析的潜在内标物。
[(13)C3,(15)N1]-labeled isodesmosine: A potential internal standard for LC-MS/MS analysis of desmosines in elastin degradation.
作者信息
Tanigawa Takahiro, Komatsu Akira, Usuki Toyonobu
机构信息
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan.
出版信息
Bioorg Med Chem Lett. 2015;25(10):2046-9. doi: 10.1016/j.bmcl.2015.03.084. Epub 2015 Apr 3.
Isodesmosine and desmosine are crosslinking amino acids that are present only in elastin. They are useful biomarkers for the degradation of elastin, which occurs during the progression of chronic obstructive pulmonary disease (COPD) and related diseases. This Letter describes the synthesis of [(13)C3,(15)N1]-labeled isodesmosine, using Chichibabin pyridine synthesis as a key reaction. The labeled isodesmosine is a potential internal standard for the quantitative LC-MS/MS analysis of desmosines in elastin degradation.
异锁链素和锁链素是仅存在于弹性蛋白中的交联氨基酸。它们是弹性蛋白降解的有用生物标志物，弹性蛋白降解发生在慢性阻塞性肺疾病（COPD）及相关疾病的进展过程中。本信函描述了以奇奇巴宾吡啶合成作为关键反应来合成[(13)C3,(15)N1]标记的异锁链素。标记的异锁链素是用于弹性蛋白降解中锁链素定量液相色谱-串联质谱分析的潜在内标。
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