Nagaraja Vinayak, Eslick Guy D
Vinayak Nagaraja, Guy D Eslick, The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Nepean Hospital, Penrith, NSW 2751, Australia.
World J Gastroenterol. 2014 Oct 28;20(40):14527-36. doi: 10.3748/wjg.v20.i40.14527.
Peptic ulcer disease continues to be issue especially due to its high prevalence in the developing world. Helicobacter pylori (H. pylori) infection associated duodenal ulcers should undergo eradication therapy. There are many regimens offered for H. pylori eradication which include triple, quadruple, or sequential therapy regimens. The central aim of this systematic review is to evaluate the evidence for H. pylori therapy from a meta-analytical outlook. The consequence of the dose, type of proton-pump inhibitor, and the length of the treatment will be debated. The most important risk factor for eradication failure is resistance to clarithromycin and metronidazole.
消化性溃疡病仍然是一个问题,特别是由于其在发展中国家的高患病率。幽门螺杆菌(H. pylori)感染相关的十二指肠溃疡应接受根除治疗。有许多用于根除幽门螺杆菌的方案,包括三联、四联或序贯治疗方案。本系统评价的核心目的是从荟萃分析的角度评估幽门螺杆菌治疗的证据。将讨论剂量、质子泵抑制剂类型和治疗时长的影响。根除失败的最重要风险因素是对克拉霉素和甲硝唑的耐药性。