Hassan Imran H, Soliman Mina, Shirazi-Nejad Ahmad R
Gastroenterology, Barnsley Hospital National Health Service (NHS) Foundation Trust, Barnsley, GBR.
Cureus. 2022 Oct 27;14(10):e30759. doi: 10.7759/cureus.30759. eCollection 2022 Oct.
Ménétrier's disease is a rare, acquired, premalignant disorder of the stomach distinguished by hypertrophic giant mucosal folds in the proximal part of the stomach (body and fundus), diminished acid secretion and excessive mucous production, resulting in hypoalbuminemia. Menetrier's is also known as hypoproteinaemic hypertrophic gastropathy and giant hypertrophic gastritis. We present a case of four siblings who presented between 2010 and 2017 with symptomatic iron deficiency anaemia or upper gastrointestinal symptoms with confirmed Ménétrier's disease. The etiology of Ménétrier's disease is unknown but it has been linked to raised TGF-α (transforming growth factor alpha protein) in the gastric mucosa causing increased signalling of epidermal growth factor. It is also associated with infections such as cytomegalovirus and . Despite these associations, there have been cases without any of these viruses detected. Diagnosis is usually made by barium swallow or endoscopic evaluation, which characteristically shows thickened gastric folds, while the biopsies' hallmark feature is massive foveolar hyperplasia. We present a case series of four siblings who presented between 2010 and 2017 with symptomatic iron deficiency anaemia or upper gastrointestinal symptoms with confirmed Ménétrier's disease.
梅内特里尔病是一种罕见的后天性癌前胃部疾病，其特征为胃近端（胃体和胃底）出现肥厚性巨大黏膜皱襞、胃酸分泌减少以及黏液分泌过多，从而导致低蛋白血症。梅内特里尔病也被称为低蛋白血症性肥厚性胃病和巨大肥厚性胃炎。我们报告了一个四兄弟姐妹的病例，他们在2010年至2017年间因有症状的缺铁性贫血或上消化道症状就诊，确诊为梅内特里尔病。梅内特里尔病的病因尚不清楚，但它与胃黏膜中转化生长因子α（TGF-α）水平升高有关，这会导致表皮生长因子信号增强。它还与巨细胞病毒等感染有关。尽管有这些关联，但也有未检测到任何这些病毒的病例。诊断通常通过钡餐或内镜评估进行，其特征性表现为胃皱襞增厚，而活检的标志性特征是大量小凹增生。我们报告了一个四兄弟姐妹的病例系列，他们在2010年至2017年间因有症状的缺铁性贫血或上消化道症状就诊，确诊为梅内特里尔病。
