TNM分期和改良Dukes分期以及结直肠癌患者的人口统计学特征。
TNM and Modified Dukes staging along with the demographic characteristics of patients with colorectal carcinoma.
作者信息
Akkoca Ayşe Neslin, Yanık Serdar, Ozdemir Zeynep Tuğba, Cihan Fatma Gökşin, Sayar Süleyman, Cincin Tarık Gandi, Cam Akın, Ozer Cahit
机构信息
Department of Family Medicine, İskenderun State Hospital Hatay.
Department of Patology, İskenderun State Hospital Hatay.
出版信息
Int J Clin Exp Med. 2014 Sep 15;7(9):2828-35. eCollection 2014.
AIM
Colon adenocarcinoma, is the most common cancer in gastrointesinal system (GIS). The whole world is an important cause of morbidity and mortality. TNM and modified Dukes classification which has great importance in the diagnosis and treatment of Colorectal cancer (CRC). TNM and Modified Dukes classification results of histopathological examination and the demographic characteristics of patients and their relation were investigated.
MATERIALS AND METHODS
Lower gastrointestinal operation results of 85 patients were examined accepted to clinical Pathology between January 1997-November 2013. Colon cancer had been diagnosed at 85 patients with pathology materials and staging was done according to the TNM and Modified Duke classification. The demographic characteristics of patients, differentiation grade, lymph node involvement, serous involvement were evaluated retrospectively.
RESULTS
In this study 37 patients (43.52%) were men and 48 (56.47%) were women. Ages of patients were between 19 and 87 with a mean age of 57.31 ± 15.31. Lymph node, differentiation, serosa involvement, Modified Dukes and TNM classification was assessed according to sex and age. TNM classification by sex was not statistically significant (p > 0.05). There was no statistically significant relationship between age and differentiation (p = 0.085). Value of differentiation increased towards from 1 to 3 inversely proportional to age. So young patients defined as well-differentiated at the conclusion. Negative relationship was evaluated between age and TNM Class variables. As a result, the relationship between age and TNM was not significant (p > 0.05). However, with increasing age the degree of staging was also found to increase. TNM classification was associated with the differentiation and it was significant (p = 0.043).
CONCLUSION
Colon cancer, when contracted at an early stage, it is suitable for surgery and curative treatment can be done with minimal morbidity and mortality. However, some of the patients have advanced disease at diagnosis and their 5-year survival rate is only 8%. Every year there is prolongation of overall survival of colon cancer. It is so common cancer type so that determination of prognostic factors, disease staging and treatment strategy which affects survival is significant.
目的
结肠腺癌是胃肠道系统（GIS）中最常见的癌症。它是全球发病和死亡的重要原因。TNM分期和改良Dukes分期在结直肠癌（CRC）的诊断和治疗中具有重要意义。本研究对组织病理学检查的TNM分期和改良Dukes分期结果以及患者的人口统计学特征及其关系进行了调查。
材料与方法
对1997年1月至2013年11月期间接受临床病理检查的85例患者的下消化道手术结果进行了检查。通过病理材料诊断出85例结肠癌患者，并根据TNM分期和改良Dukes分期进行分期。对患者的人口统计学特征、分化程度、淋巴结受累情况、浆膜受累情况进行了回顾性评估。
结果
本研究中，男性患者37例（43.52%），女性患者48例（56.47%）。患者年龄在19岁至87岁之间，平均年龄为57.31±15.31岁。根据性别和年龄对淋巴结、分化程度、浆膜受累情况、改良Dukes分期和TNM分期进行了评估。按性别进行的TNM分期差异无统计学意义（p>0.05）。年龄与分化程度之间无统计学意义（p=0.085）。分化程度值从1到3升高，与年龄成反比。因此，年轻患者最终被定义为高分化。年龄与TNM分期变量之间呈负相关。结果显示，年龄与TNM分期之间差异无统计学意义（p>0.05）。然而，随着年龄的增加，分期程度也随之增加。TNM分期与分化程度相关，差异有统计学意义（p=0.043）。
结论
结肠癌在早期发病时适合手术治疗，且能以最低的发病率和死亡率进行根治性治疗。然而，部分患者在诊断时已处于疾病晚期，其5年生存率仅为8%。每年结肠癌的总生存期都在延长。由于它是一种非常常见的癌症类型，因此确定影响生存的预后因素、疾病分期和治疗策略具有重要意义。
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